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DYT1_ARATH
ID   DYT1_ARATH              Reviewed;         207 AA.
AC   O81900; A7Y5V9;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Transcription factor DYT1 {ECO:0000305};
DE   AltName: Full=Basic helix-loop-helix protein 22;
DE            Short=AtbHLH22;
DE            Short=bHLH 22;
DE   AltName: Full=Protein DYSFUNCTIONAL TAPETUM 1 {ECO:0000303|PubMed:16831835};
DE   AltName: Full=Transcription factor EN 49;
DE   AltName: Full=bHLH transcription factor bHLH022;
GN   Name=DYT1 {ECO:0000303|PubMed:16831835}; Synonyms=BHLH22, EN49;
GN   OrderedLocusNames=At4g21330; ORFNames=T6K22.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=16831835; DOI=10.1242/dev.02463;
RA   Zhang W., Sun Y., Timofejeva L., Chen C., Grossniklaus U., Ma H.;
RT   "Regulation of Arabidopsis tapetum development and function by
RT   DYSFUNCTIONAL TAPETUM1 (DYT1) encoding a putative bHLH transcription
RT   factor.";
RL   Development 133:3085-3095(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Cvi-0;
RX   PubMed=17656687; DOI=10.1126/science.1143153;
RA   Tang C., Toomajian C., Sherman-Broyles S., Plagnol V., Guo Y.-L., Hu T.T.,
RA   Clark R.M., Nasrallah J.B., Weigel D., Nordborg M.;
RT   "The evolution of selfing in Arabidopsis thaliana.";
RL   Science 317:1070-1072(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12679534; DOI=10.1093/molbev/msg088;
RA   Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT   "The basic helix-loop-helix transcription factor family in plants: a
RT   genome-wide study of protein structure and functional diversity.";
RL   Mol. Biol. Evol. 20:735-747(2003).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=12897250; DOI=10.1105/tpc.013839;
RA   Toledo-Ortiz G., Huq E., Quail P.H.;
RT   "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL   Plant Cell 15:1749-1770(2003).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=14600211; DOI=10.1105/tpc.151140;
RA   Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA   Jakoby M., Werber M., Weisshaar B.;
RT   "Update on the basic helix-loop-helix transcription factor gene family in
RT   Arabidopsis thaliana.";
RL   Plant Cell 15:2497-2502(2003).
CC   -!- FUNCTION: Transcription factor. Involved in the control of tapetum
CC       development. Required for male fertility and pollen differentiation,
CC       especially during callose deposition. {ECO:0000269|PubMed:16831835}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in anthers, and, to a lower
CC       extent, in young inflorescences undergoing meiosis and siliques.
CC       {ECO:0000269|PubMed:16831835}.
CC   -!- DEVELOPMENTAL STAGE: First observed in floral meristem and early anther
CC       primordia. Later detected in archesporial cells. From stage 4 to early
CC       stage 5, weakly expressed in precursors of the middle layer, tapetum
CC       and meiocytes. Strongly expressed in the tapetum from late anther stage
CC       5 to early stage 6, and at a lower level in meiocytes.
CC       {ECO:0000269|PubMed:16831835}.
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DR   EMBL; EF637083; ABV21209.1; -; Genomic_DNA.
DR   EMBL; AL031187; CAA20198.1; -; Genomic_DNA.
DR   EMBL; AL161554; CAB79132.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE84442.1; -; Genomic_DNA.
DR   PIR; T05175; T05175.
DR   RefSeq; NP_193864.1; NM_118253.1.
DR   AlphaFoldDB; O81900; -.
DR   SMR; O81900; -.
DR   BioGRID; 13174; 5.
DR   STRING; 3702.AT4G21330.1; -.
DR   PaxDb; O81900; -.
DR   PRIDE; O81900; -.
DR   EnsemblPlants; AT4G21330.1; AT4G21330.1; AT4G21330.
DR   GeneID; 827883; -.
DR   Gramene; AT4G21330.1; AT4G21330.1; AT4G21330.
DR   KEGG; ath:AT4G21330; -.
DR   Araport; AT4G21330; -.
DR   TAIR; locus:2141206; AT4G21330.
DR   eggNOG; ENOG502S0WD; Eukaryota.
DR   HOGENOM; CLU_083457_0_0_1; -.
DR   InParanoid; O81900; -.
DR   OMA; PKITKMS; -.
DR   OrthoDB; 1323520at2759; -.
DR   PhylomeDB; O81900; -.
DR   PRO; PR:O81900; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O81900; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IPI:TAIR.
DR   GO; GO:0048658; P:anther wall tapetum development; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcription factor DYT1"
FT                   /id="PRO_0000358842"
FT   DOMAIN          28..77
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        3
FT                   /note="G -> R (in Ref. 1; ABV21209)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  24022 MW;  EBB0CCAE1EB62F05 CRC64;
     MGGGSRFQEP VRMSRRKQVT KEKEEDENFK SPNLEAERRR REKLHCRLMA LRSHVPIVTN
     MTKASIVEDA ITYIGELQNN VKNLLETFHE MEEAPPEIDE EQTDPMIKPE VETSDLNEEM
     KKLGIEENVQ LCKIGERKFW LKIITEKRDG IFTKFMEVMR FLGFEIIDIS LTTSNGAILI
     SASVQTQELC DVEQTKDFLL EVMRSNP
 
 
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