DYT2B_MOUSE
ID DYT2B_MOUSE Reviewed; 144 AA.
AC Q9CQ66;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Dynein light chain Tctex-type protein 2B {ECO:0000305};
DE AltName: Full=Tctex1 domain-containing protein 2;
GN Name=Dynlt2b; Synonyms=Tctex1d2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, Testis, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein
CC complex that drives the movement of cargos along microtubules within
CC cilia and flagella in concert with the intraflagellar transport (IFT)
CC system. Required for proper retrograde ciliary transport.
CC {ECO:0000250|UniProtKB:Q8WW35}.
CC -!- SUBUNIT: Light chain of the cytoplasmic dynein complex 2, a
CC multisubunit complex composed at least of eleven different proteins.
CC The cytoplasmic dynein 2 complex consists of two catalytic heavy chains
CC (HCs) and a number of non-catalytic subunits presented by intermediate
CC chains (ICs), light intermediate chains (LICs) and light chains (LCs).
CC Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2
CC and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain
CC (DYNLT2B) are unique to the dynein-2 complex, but a subset of the light
CC chains are also shared by dynein-1 and dynein-2 complexes. The dimer
CC DYNLT2B-DYNLT1/DYNLT3 interacts with DYNC2I1; this interaction is
CC crucial for retrograde trafficking of ciliary proteins.
CC {ECO:0000250|UniProtKB:Q8WW35}.
CC -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q8WW35}.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000305}.
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DR EMBL; AK002589; BAB22210.1; -; mRNA.
DR EMBL; AK007178; BAB24886.1; -; mRNA.
DR EMBL; AK010027; BAB26652.1; -; mRNA.
DR EMBL; BC059716; AAH59716.1; -; mRNA.
DR CCDS; CCDS37312.1; -.
DR RefSeq; NP_079605.1; NM_025329.3.
DR AlphaFoldDB; Q9CQ66; -.
DR SMR; Q9CQ66; -.
DR STRING; 10090.ENSMUSP00000014220; -.
DR iPTMnet; Q9CQ66; -.
DR PhosphoSitePlus; Q9CQ66; -.
DR MaxQB; Q9CQ66; -.
DR PaxDb; Q9CQ66; -.
DR PRIDE; Q9CQ66; -.
DR ProteomicsDB; 263084; -.
DR DNASU; 66061; -.
DR Ensembl; ENSMUST00000014220; ENSMUSP00000014220; ENSMUSG00000014075.
DR GeneID; 66061; -.
DR KEGG; mmu:66061; -.
DR UCSC; uc007yyt.1; mouse.
DR CTD; 255758; -.
DR MGI; MGI:1913311; Dynlt2b.
DR VEuPathDB; HostDB:ENSMUSG00000014075; -.
DR eggNOG; KOG4108; Eukaryota.
DR GeneTree; ENSGT00940000160019; -.
DR HOGENOM; CLU_097204_8_0_1; -.
DR InParanoid; Q9CQ66; -.
DR OMA; YSMRPAF; -.
DR OrthoDB; 1434909at2759; -.
DR PhylomeDB; Q9CQ66; -.
DR TreeFam; TF313904; -.
DR Reactome; R-MMU-5620924; Intraflagellar transport.
DR BioGRID-ORCS; 66061; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tctex1d2; mouse.
DR PRO; PR:Q9CQ66; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9CQ66; protein.
DR Bgee; ENSMUSG00000014075; Expressed in seminiferous tubule of testis and 222 other tissues.
DR ExpressionAtlas; Q9CQ66; baseline and differential.
DR Genevisible; Q9CQ66; MM.
DR GO; GO:0005930; C:axoneme; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0097546; C:ciliary base; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; ISO:MGI.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0031021; C:interphase microtubule organizing center; ISO:MGI.
DR GO; GO:0000922; C:spindle pole; ISO:MGI.
DR GO; GO:0045505; F:dynein intermediate chain binding; ISO:MGI.
DR GO; GO:0060271; P:cilium assembly; ISO:MGI.
DR GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:1902017; P:regulation of cilium assembly; ISO:MGI.
DR GO; GO:1905799; P:regulation of intraciliary retrograde transport; ISS:UniProtKB.
DR Gene3D; 3.30.1140.40; -; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255; PTHR21255; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..144
FT /note="Dynein light chain Tctex-type protein 2B"
FT /id="PRO_0000316870"
SQ SEQUENCE 144 AA; 16499 MW; BF220758B23DCF4A CRC64;
MAVSFRGLSL SAHSEGLSEV DKNSGEPENT YILRPIFQQR FRPSVVKDCI HTVLKEELAS
AEYSPDEMPQ LTKRLSEMIK DKLKELGYDR YKMVVQVVIG EQRGEGVFMA ARCFWDADTD
NYTHDVFMND SLFCVVAAFG CFYY