ID   DYTN_DANRE              Reviewed;         648 AA.
AC   A2CI97;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Dystrotelin;
GN   Name=dytn;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17233888; DOI=10.1186/1471-2164-8-19;
RA   Jin H., Tan S., Hermanowski J., Boehm S., Pacheco S., McCauley J.M.,
RA   Greener M.J., Hinits Y., Hughes S.M., Sharpe P.T., Roberts R.G.;
RT   "The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues
RT   and old isoforms.";
RL   BMC Genomics 8:19-19(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ443726; ABD98314.1; -; mRNA.
DR   RefSeq; NP_001074056.1; NM_001080587.1.
DR   RefSeq; XP_009300510.1; XM_009302235.2.
DR   AlphaFoldDB; A2CI97; -.
DR   SMR; A2CI97; -.
DR   STRING; 7955.ENSDARP00000095514; -.
DR   PaxDb; A2CI97; -.
DR   Ensembl; ENSDART00000104744; ENSDARP00000095514; ENSDARG00000071025.
DR   GeneID; 563097; -.
DR   KEGG; dre:563097; -.
DR   CTD; 391475; -.
DR   ZFIN; ZDB-GENE-070124-2; dytn.
DR   eggNOG; KOG4286; Eukaryota.
DR   GeneTree; ENSGT00940000162403; -.
DR   HOGENOM; CLU_027773_0_0_1; -.
DR   InParanoid; A2CI97; -.
DR   OMA; VRCHACK; -.
DR   OrthoDB; 598837at2759; -.
DR   PhylomeDB; A2CI97; -.
DR   TreeFam; TF343849; -.
DR   PRO; PR:A2CI97; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000071025; Expressed in testis and 17 other tissues.
DR   ExpressionAtlas; A2CI97; baseline.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR   Gene3D; 3.30.60.90; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015153; EF-hand_dom_typ1.
DR   InterPro; IPR015154; EF-hand_dom_typ2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   Pfam; PF09068; EF-hand_2; 1.
DR   Pfam; PF09069; EF-hand_3; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF47473; SSF47473; 2.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Membrane; Metal-binding; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..648
FT                   /note="Dystrotelin"
FT                   /id="PRO_0000298936"
FT   ZN_FING         223..279
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   REGION          455..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          367..446
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        458..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         228
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         231
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         243
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         246
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         252
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         255
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         269
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ   SEQUENCE   648 AA;  73398 MW;  3037FADB5F3BED81 CRC64;
     MDLDNIEGLN EVRLAVYRAA LKLRSLQKLC QMNLVLLQDL RPILNTLWSS GESTISLAQE
     DVQQHLEELF RSISPELPDQ AVTEATDQTT RLLFKLFDRG QTGVILLRSV EAALIALCGD
     TLSAKQRALF RLAESYSGNQ ESDRGSISRS ALRVLLEDLS QVPAVVQENH VFGHAETAVS
     SCFNGVISAG VTEEHFIWWL QSEPRLLLWL STLYRISVSE AVQHRVHCHA CKAFPITGLR
     YRCLKCLNVH LCQSCFLTER RSRKHKPSHS VLEYCTQPSW KESMASLASS ARHALVPRHT
     RREAERKRAL RAGSSAELRY SASNPALQFA AYADTHDAAA EASQTAAPAA VTVESKSLQT
     EEIQIPQRET AELQKDISVT QKAMRDLQRD KWLLEKEFQV WRVAAQSEHD SLEDKCSELK
     SMMETLNQHN QHLEEELDTV RHLLSLRHKE ELKTSHSNLQ LEQDGSINEN NWTQPGLLKP
     HESSSTEHEV EERGTRQERR FEEEEDTLYD LSEDISTNLD DSESILPQDV HTALAQREEE
     ELQEEEEGLH EKEEGLPTEE EELQHDRQDP SFFHGCMSDF APDGHSDDSE MDDEEDLCEL
     VQRLRNELSL YTASGSVCLQ KEMLMTAAEG VRDSVSHLVT SVKSSSLA