ID   DYTN_HUMAN              Reviewed;         578 AA.
AC   A2CJ06;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Dystrotelin;
GN   Name=DYTN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17233888; DOI=10.1186/1471-2164-8-19;
RA   Jin H., Tan S., Hermanowski J., Boehm S., Pacheco S., McCauley J.M.,
RA   Greener M.J., Hinits Y., Hughes S.M., Sharpe P.T., Roberts R.G.;
RT   "The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues
RT   and old isoforms.";
RL   BMC Genomics 8:19-19(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
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DR   EMBL; DQ516347; ABF55377.1; -; mRNA.
DR   CCDS; CCDS46502.1; -.
DR   RefSeq; NP_001087199.1; NM_001093730.1.
DR   AlphaFoldDB; A2CJ06; -.
DR   SMR; A2CJ06; -.
DR   BioGRID; 133933; 1.
DR   STRING; 9606.ENSP00000396593; -.
DR   iPTMnet; A2CJ06; -.
DR   PhosphoSitePlus; A2CJ06; -.
DR   BioMuta; DYTN; -.
DR   EPD; A2CJ06; -.
DR   jPOST; A2CJ06; -.
DR   PaxDb; A2CJ06; -.
DR   PeptideAtlas; A2CJ06; -.
DR   PRIDE; A2CJ06; -.
DR   ProteomicsDB; 437; -.
DR   Antibodypedia; 67876; 71 antibodies from 12 providers.
DR   DNASU; 391475; -.
DR   Ensembl; ENST00000452335.2; ENSP00000396593.2; ENSG00000232125.5.
DR   GeneID; 391475; -.
DR   KEGG; hsa:391475; -.
DR   MANE-Select; ENST00000452335.2; ENSP00000396593.2; NM_001093730.1; NP_001087199.1.
DR   UCSC; uc002vbr.1; human.
DR   CTD; 391475; -.
DR   DisGeNET; 391475; -.
DR   GeneCards; DYTN; -.
DR   HGNC; HGNC:23279; DYTN.
DR   HPA; ENSG00000232125; Not detected.
DR   MIM; 618510; gene.
DR   neXtProt; NX_A2CJ06; -.
DR   OpenTargets; ENSG00000232125; -.
DR   PharmGKB; PA162384136; -.
DR   VEuPathDB; HostDB:ENSG00000232125; -.
DR   eggNOG; KOG4286; Eukaryota.
DR   GeneTree; ENSGT00940000162403; -.
DR   HOGENOM; CLU_027773_0_0_1; -.
DR   InParanoid; A2CJ06; -.
DR   OMA; QKSHPVI; -.
DR   OrthoDB; 598837at2759; -.
DR   PhylomeDB; A2CJ06; -.
DR   TreeFam; TF326090; -.
DR   PathwayCommons; A2CJ06; -.
DR   SignaLink; A2CJ06; -.
DR   BioGRID-ORCS; 391475; 11 hits in 1061 CRISPR screens.
DR   ChiTaRS; DYTN; human.
DR   GenomeRNAi; 391475; -.
DR   Pharos; A2CJ06; Tdark.
DR   PRO; PR:A2CJ06; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A2CJ06; protein.
DR   Bgee; ENSG00000232125; Expressed in monocyte and 9 other tissues.
DR   ExpressionAtlas; A2CJ06; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR   Gene3D; 3.30.60.90; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015153; EF-hand_dom_typ1.
DR   InterPro; IPR015154; EF-hand_dom_typ2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   Pfam; PF09068; EF-hand_2; 1.
DR   Pfam; PF09069; EF-hand_3; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF47473; SSF47473; 2.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Membrane; Metal-binding; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..578
FT                   /note="Dystrotelin"
FT                   /id="PRO_0000298934"
FT   ZN_FING         223..279
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   REGION          382..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          322..351
FT                   /evidence="ECO:0000255"
FT   COILED          503..537
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        384..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..450
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         228
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         231
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         243
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         246
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         252
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         255
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   BINDING         269
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT   VARIANT         241
FT                   /note="Y -> C (in dbSNP:rs16838593)"
FT                   /id="VAR_050960"
FT   VARIANT         474
FT                   /note="Q -> K (in dbSNP:rs2115591)"
FT                   /id="VAR_050961"
SQ   SEQUENCE   578 AA;  65320 MW;  EC7BC442A8F38644 CRC64;
     MDPDKQDALN SIENSIYRTA FKLQSVQTLC QLDLIDSSLI QQVLLRPSFW EARKHSLSVQ
     QLSQALQELF QKAREENPGQ VHPRAPELTL SLLTTMYNSK GTGFLQLMPA AAALITLSGD
     SPLSKYRALF QLYAENSRGG YDSGPRMTRR VLRKLLTDLQ QIPTFVGESR ALCPVESATR
     SCFQGVLSPA IKEEKFLSWV QSEPPILLWL PTCHRLSAAE RVTHPARCTL CRTFPITGLR
     YRCLKCLNFD ICQMCFLSGL HSKSHQKSHP VIEHCIQMSA MQNTKLLFRT LRNNLLQGRC
     RKKEAARRQQ LLDQVNPKGV PHHAQARLLK KQLNQYKDKL QAIYTSQEER ICRFETRIHK
     LKTNQDSLWT KLQQIRRDLQ ARLQPPGPSS SSFQNVGNKV DHSSTEKVPK GGDYLQIKNA
     TEDASTGEPL PKLDEVDRSH RSHTNAEHAL RNPESPETTL HSTRAQSQTQ KMPQKVISAL
     PSYQEGLKQD IPKMVPAEMS SPALAAVEKK EAGNIKERKD ELEEEELQEL LSKLMDAFNL
     ETPSGPESSV NMDLYSGAQR VCRAFSALVD QIALPNLK