DYTN_MOUSE
ID DYTN_MOUSE Reviewed; 653 AA.
AC A2CI98; Q5F254;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Dystrotelin;
GN Name=Dytn; Synonyms=Gm215;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=17233888; DOI=10.1186/1471-2164-8-19;
RA Jin H., Tan S., Hermanowski J., Boehm S., Pacheco S., McCauley J.M.,
RA Greener M.J., Hinits Y., Hughes S.M., Sharpe P.T., Roberts R.G.;
RT "The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues
RT and old isoforms.";
RL BMC Genomics 8:19-19(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17233888}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the nervous and muscular
CC tissues. {ECO:0000269|PubMed:17233888}.
CC -!- DEVELOPMENTAL STAGE: At 10.5 dpc, expressed largely in the brain and
CC neural tube. {ECO:0000269|PubMed:17233888}.
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DR EMBL; DQ443727; ABD98315.1; -; mRNA.
DR EMBL; AL645534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35595.1; -.
DR RefSeq; NP_001075127.1; NM_001081658.1.
DR AlphaFoldDB; A2CI98; -.
DR SMR; A2CI98; -.
DR STRING; 10090.ENSMUSP00000087787; -.
DR iPTMnet; A2CI98; -.
DR PhosphoSitePlus; A2CI98; -.
DR PaxDb; A2CI98; -.
DR PRIDE; A2CI98; -.
DR ProteomicsDB; 277428; -.
DR Antibodypedia; 67876; 71 antibodies from 12 providers.
DR Ensembl; ENSMUST00000090313; ENSMUSP00000087787; ENSMUSG00000069085.
DR GeneID; 241073; -.
DR KEGG; mmu:241073; -.
DR UCSC; uc007bgi.1; mouse.
DR CTD; 391475; -.
DR MGI; MGI:2685061; Dytn.
DR VEuPathDB; HostDB:ENSMUSG00000069085; -.
DR eggNOG; KOG4286; Eukaryota.
DR GeneTree; ENSGT00940000162403; -.
DR HOGENOM; CLU_027773_0_0_1; -.
DR InParanoid; A2CI98; -.
DR OMA; QKSHPVI; -.
DR OrthoDB; 598837at2759; -.
DR PhylomeDB; A2CI98; -.
DR TreeFam; TF326090; -.
DR BioGRID-ORCS; 241073; 1 hit in 73 CRISPR screens.
DR PRO; PR:A2CI98; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; A2CI98; protein.
DR Bgee; ENSMUSG00000069085; Expressed in lens of camera-type eye and 3 other tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0099536; P:synaptic signaling; IBA:GO_Central.
DR Gene3D; 3.30.60.90; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; SSF47473; 2.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Membrane; Metal-binding; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..653
FT /note="Dystrotelin"
FT /id="PRO_0000298935"
FT ZN_FING 223..279
FT /note="ZZ-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT COILED 384..411
FT /evidence="ECO:0000255"
FT BINDING 228
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 231
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 243
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 246
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 252
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 255
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 265
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 269
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ SEQUENCE 653 AA; 74059 MW; 7C1A4A6EF11DF76F CRC64;
MDPSKQGTLN RVENSVYRTA FKLRSVQTLC QLDLMDSFLI QQVLWRGRSG ESTETSISVQ
QLFQELRELF QRTGMGNAAQ VHPRAPELTL SLLMAMFDRT GSGILKRQPV AAALVALSGD
SPLTKYRAFF QLYAEKNRRG DDSQARMTRR VLRALLTDLQ QIPTVVGESY TLRPVESAIH
SCFRGVLSSG IKEEKFLSWA QSEPLVLLWL PTCYRLSAAE TVTHPVRCSV CRTFPIIGLR
YHCLKCLDFD ICELCFLSGL HKNSHEKSHT VMEECVQMSA TENTKLLFRS LRNNLPQKRQ
RVGAVGRQWL LDQLASRDSA SHGPARLCLQ YKCPKAPGYA SSRRAVETAA TGVLCQRPSP
ALQGNHNRHG QTIVNIKNEL WRTRDSLNTL LRERRLLRKQ LHRYKQKLQG TYALQEEQNC
RFETKIRELT TNQDNLWTKL QQMRRDLQAM LQPLHPSSSP QTTASKIFHS LPDDGIRRGG
DSSHIKRVTR DGPEWELLPN SAKVDRKHKC QASSGKALPD SEPQEIILQS TRKQNHPQKM
LSKVHSSPSA HQQDTLQIPP TEVKIPAQTL SAGKEMESCS EKRNNLEDEE LQALLPRLLD
AFDLDSPTGL QPLMDMELYG RAQQVCRAFS VLVDQITLPT WSEEESRLKG PLV
