DZAN1_HUMAN
ID DZAN1_HUMAN Reviewed; 752 AA.
AC Q9NVP4; B7ZLZ4; Q4F7X1; Q5QPD9; Q5QPE0; Q68DN8; Q6ZMX9; Q96NF0; Q9H1E0;
AC Q9H442;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Double zinc ribbon and ankyrin repeat-containing protein 1;
GN Name=DZANK1; Synonyms=C20orf12, C20orf84;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Hair follicle dermal papilla, Neuron, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 250-752 (ISOFORM 5).
RA Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M.,
RA Huang B., Lin L., Yang S.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9NVP4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NVP4-2; Sequence=VSP_042090, VSP_042093, VSP_042095;
CC Name=3;
CC IsoId=Q9NVP4-3; Sequence=VSP_042096, VSP_042097;
CC Name=4;
CC IsoId=Q9NVP4-4; Sequence=VSP_042091, VSP_042092;
CC Name=5;
CC IsoId=Q9NVP4-5; Sequence=VSP_042094;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91706.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB70949.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK001462; BAA91706.1; ALT_INIT; mRNA.
DR EMBL; AK055544; BAB70949.1; ALT_SEQ; mRNA.
DR EMBL; AK131451; BAD18596.1; -; mRNA.
DR EMBL; CR749327; CAH18182.1; -; mRNA.
DR EMBL; AL049646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10244.1; -; Genomic_DNA.
DR EMBL; BC144153; AAI44154.1; -; mRNA.
DR EMBL; DQ104738; AAZ13595.1; -; mRNA.
DR CCDS; CCDS46582.1; -. [Q9NVP4-1]
DR RefSeq; NP_001092877.1; NM_001099407.1. [Q9NVP4-1]
DR RefSeq; XP_005260800.1; XM_005260743.3.
DR RefSeq; XP_011527577.1; XM_011529275.2.
DR RefSeq; XP_016883409.1; XM_017027920.1. [Q9NVP4-2]
DR AlphaFoldDB; Q9NVP4; -.
DR SMR; Q9NVP4; -.
DR BioGRID; 120483; 14.
DR IntAct; Q9NVP4; 3.
DR STRING; 9606.ENSP00000262547; -.
DR iPTMnet; Q9NVP4; -.
DR PhosphoSitePlus; Q9NVP4; -.
DR BioMuta; DZANK1; -.
DR DMDM; 363548518; -.
DR EPD; Q9NVP4; -.
DR jPOST; Q9NVP4; -.
DR MassIVE; Q9NVP4; -.
DR PaxDb; Q9NVP4; -.
DR PeptideAtlas; Q9NVP4; -.
DR PRIDE; Q9NVP4; -.
DR ProteomicsDB; 82839; -. [Q9NVP4-1]
DR ProteomicsDB; 82840; -. [Q9NVP4-2]
DR ProteomicsDB; 82841; -. [Q9NVP4-3]
DR ProteomicsDB; 82842; -. [Q9NVP4-4]
DR ProteomicsDB; 82843; -. [Q9NVP4-5]
DR Antibodypedia; 54096; 25 antibodies from 10 providers.
DR DNASU; 55184; -.
DR Ensembl; ENST00000262547.9; ENSP00000262547.5; ENSG00000089091.16. [Q9NVP4-1]
DR Ensembl; ENST00000358866.10; ENSP00000351734.6; ENSG00000089091.16. [Q9NVP4-1]
DR Ensembl; ENST00000609267.5; ENSP00000477046.1; ENSG00000089091.16. [Q9NVP4-3]
DR GeneID; 55184; -.
DR KEGG; hsa:55184; -.
DR UCSC; uc002wqq.5; human. [Q9NVP4-1]
DR CTD; 55184; -.
DR DisGeNET; 55184; -.
DR GeneCards; DZANK1; -.
DR HGNC; HGNC:15858; DZANK1.
DR HPA; ENSG00000089091; Low tissue specificity.
DR neXtProt; NX_Q9NVP4; -.
DR OpenTargets; ENSG00000089091; -.
DR PharmGKB; PA25660; -.
DR VEuPathDB; HostDB:ENSG00000089091; -.
DR eggNOG; ENOG502QTJR; Eukaryota.
DR GeneTree; ENSGT00390000000549; -.
DR HOGENOM; CLU_024089_0_0_1; -.
DR InParanoid; Q9NVP4; -.
DR OMA; VECGSMV; -.
DR OrthoDB; 391157at2759; -.
DR PhylomeDB; Q9NVP4; -.
DR TreeFam; TF351270; -.
DR PathwayCommons; Q9NVP4; -.
DR SignaLink; Q9NVP4; -.
DR BioGRID-ORCS; 55184; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; DZANK1; human.
DR GenomeRNAi; 55184; -.
DR Pharos; Q9NVP4; Tdark.
DR PRO; PR:Q9NVP4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NVP4; protein.
DR Bgee; ENSG00000089091; Expressed in sperm and 135 other tissues.
DR ExpressionAtlas; Q9NVP4; baseline and differential.
DR Genevisible; Q9NVP4; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042462; P:eye photoreceptor cell development; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR025874; DZR.
DR InterPro; IPR026876; Fn3_assoc_repeat.
DR Pfam; PF12773; DZR; 1.
DR Pfam; PF13287; Fn3_assoc; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Metal-binding; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..752
FT /note="Double zinc ribbon and ankyrin repeat-containing
FT protein 1"
FT /id="PRO_0000066986"
FT REPEAT 605..636
FT /note="ANK 1"
FT REPEAT 640..669
FT /note="ANK 2"
FT ZN_FING 211..270
FT /note="DZANK-type 1"
FT ZN_FING 339..387
FT /note="DZANK-type 2"
FT REGION 164..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C008"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VAR_SEQ 1..173
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042090"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_042091"
FT VAR_SEQ 115..180
FT /note="NVENVLKDSSRQEFKNGFVGSKLKKKYKNSENQRSWNVNLRKFPESPLEIPA
FT YGGGSGSRPPTRQS -> MLTLESFQRVHWKSQLMVEDQVLDHPPASPRQDTVPFTFKS
FT FLFGHSMEIRPWKRKGRTLFRRLLF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_042092"
FT VAR_SEQ 174..180
FT /note="RPPTRQS -> MLTLESF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042093"
FT VAR_SEQ 319..359
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_042094"
FT VAR_SEQ 414
FT /note="E -> EPRCAWQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042095"
FT VAR_SEQ 538..574
FT /note="NLYLNKAVNFSDHLLSSAAEGDGGLCGSRSSWVSDYS -> VRKLRLREVKQ
FT PASSKGTKLVSGRPRIHTWQPETFPS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042096"
FT VAR_SEQ 575..752
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042097"
FT CONFLICT 272
FT /note="A -> V (in Ref. 1; BAB70949)"
FT /evidence="ECO:0000305"
FT CONFLICT 603
FT /note="I -> L (in Ref. 6; AAZ13595)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 752 AA; 82192 MW; CF2DCF2969706264 CRC64;
MTAGSVCVPQ IIPLRVPQPG KANHEIDNNT LLEMKSDTPD VNIYYTLDGS KPEFLKRIGY
GENNTFKYIK PITLPDGKIQ VKAIAVSKDC RQSGIVTKVF HVDYEPPNIV SPEDNVENVL
KDSSRQEFKN GFVGSKLKKK YKNSENQRSW NVNLRKFPES PLEIPAYGGG SGSRPPTRQS
QSPGFAHVSG QKCLTSTEIM RIQRETDFLK CAHCLAPRPS DPFARFCQEC GSPVPPIFGC
RLPPPEGAQM GLCAECRSLV PMNTPICVVC EAPLALQLQP QASLHLKEKV ICRACGTGNP
AHLRYCVTCE GALPSSQESM CSGDKAPPPP TQKGGTISCY RCGRWNLWEA SFCGWCGAML
GIPAGCSVCP KCGASNHLSA RFCGSCGICV KSLVKLSLDR SLALAAEEPR PFSESLNIPL
PRSDVGTKRD IGTQTVGLFY PSGKLLAKKE QELASQKQRQ EKMSDHKPLL TAISPGRGYW
RRQLDHISAH LRCYAQNNPE FRALIAEPRM GKLISATVHE DGCEVSIRLN YSQVSNKNLY
LNKAVNFSDH LLSSAAEGDG GLCGSRSSWV SDYSQSTSDT IEKIKRIKNF KTKTFQEKKE
QLIPENRLLL KEVGPTGEGR VSVIEQLLDE GADPNCCDED NRPVITVAVM NKHHEAIPVL
VQRGADIDQQ WGPLRNTALH EATLLGLAGR ESTATLLGCN ASIQKKNAGG QTAYDLALNT
GDDLVTSLFA AKFGQGLEDQ LAQTRSLSLD DC
