E1126_AMBCJ
ID E1126_AMBCJ Reviewed; 90 AA.
AC A0A023FF81;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 11-JUN-2014, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=Evasin P1126 {ECO:0000303|PubMed:31167786};
DE Flags: Precursor;
OS Amblyomma cajennense (Cayenne tick) (Acarus cajennensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Amblyomminae; Amblyomma.
OX NCBI_TaxID=34607;
RN [1] {ECO:0000312|EMBL:JAC19589.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Uberlandia {ECO:0000312|EMBL:JAC19589.1};
RC TISSUE=Salivary gland {ECO:0000312|EMBL:JAC19589.1};
RX PubMed=25201527; DOI=10.1186/1756-3305-7-430;
RA Garcia G.R., Gardinassi L.G., Ribeiro J.M., Anatriello E., Ferreira B.R.,
RA Moreira H.N., Mafra C., Martins M.M., Szabo M.P., de Miranda-Santos I.K.,
RA Maruyama S.R.;
RT "The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma
RT cajennense ticks, uncovered by 454-based RNA-seq.";
RL Parasit. Vectors 7:430-430(2014).
RN [2] {ECO:0000305}
RP FUNCTION.
RX PubMed=31167786; DOI=10.1074/jbc.ra119.008817;
RA Lee A.W., Deruaz M., Lynch C., Davies G., Singh K., Alenazi Y.,
RA Eaton J.R.O., Kawamura A., Shaw J., Proudfoot A.E.I., Dias J.M.,
RA Bhattacharya S.;
RT "A knottin scaffold directs the CXC-chemokine-binding specificity of tick
RT evasins.";
RL J. Biol. Chem. 294:11199-11212(2019).
CC -!- FUNCTION: Salivary chemokine-binding protein which binds to host
CC chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL10 and
CC CXCL11. {ECO:0000269|PubMed:31167786}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; GBBK01004893; JAC19589.1; -; mRNA.
DR AlphaFoldDB; A0A023FF81; -.
DR SMR; A0A023FF81; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019958; F:C-X-C chemokine binding; IDA:UniProtKB.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..90
FT /note="Evasin P1126"
FT /evidence="ECO:0000255"
FT /id="PRO_5001515397"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 46..62
FT /evidence="ECO:0000250|UniProtKB:P0C8E8"
FT DISULFID 50..64
FT /evidence="ECO:0000250|UniProtKB:P0C8E8"
FT DISULFID 58..75
FT /evidence="ECO:0000250|UniProtKB:P0C8E8"
SQ SEQUENCE 90 AA; 9826 MW; 33282EDCC28097F9 CRC64;
MTSHSAVRIA IFAVIALHSI FECLSKPQIL QRTDKSTDSE WDPQTCPETC IPSKNITCSD
GCVCVKLGEE EEGTCFNMTG VDWLGSPSDD