ID   E1156_IXORI             Reviewed;         108 AA.
AC   V5HBW0;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Evasin P1156 {ECO:0000303|PubMed:29679010};
DE   Flags: Precursor;
OS   Ixodes ricinus (Common tick) (Acarus ricinus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=34613 {ECO:0000312|EMBL:JAB72437.1};
RN   [1] {ECO:0000312|EMBL:JAB72437.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=25765539; DOI=10.1038/srep09103;
RA   Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT   "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT   and midguts when blood feeding on the vertebrate host.";
RL   Sci. Rep. 5:9103-9103(2015).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=29679010; DOI=10.1038/s41598-018-24568-9;
RA   Alenazi Y., Singh K., Davies G., Eaton J.R.O., Elders P., Kawamura A.,
RA   Bhattacharya S.;
RT   "Genetically engineered two-warhead evasins provide a method to achieve
RT   precision targeting of disease-relevant chemokine subsets.";
RL   Sci. Rep. 8:6333-6333(2018).
CC   -!- FUNCTION: Salivary chemokine-binding protein which has chemokine-
CC       neutralizing activity and binds to host chemokines CXCL1, CXCL2, CXCL3,
CC       CXCL5, CXCL6 and CXCL8. {ECO:0000269|PubMed:29679010}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; GANP01012031; JAB72437.1; -; mRNA.
DR   AlphaFoldDB; V5HBW0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019956; F:chemokine binding; IDA:UniProtKB.
DR   GO; GO:1900137; P:negative regulation of chemokine activity; IDA:UniProtKB.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..108
FT                   /note="Evasin P1156"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004735646"
FT   REGION          89..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   DISULFID        41..63
FT                   /evidence="ECO:0000250|UniProtKB:P0C8E8"
FT   DISULFID        45..65
FT                   /evidence="ECO:0000250|UniProtKB:P0C8E8"
FT   DISULFID        56..76
FT                   /evidence="ECO:0000250|UniProtKB:P0C8E8"
SQ   SEQUENCE   108 AA;  11969 MW;  1941C7C73D78ECD4 CRC64;
     MEVKTYAFLQ IAVFIFLGMQ IFASLTDAAD DDNELFTVQY CGMNCTKDEG GTWTGCTGKK
     EGCKCYHESG KNYGLCLSTE YTDFSQYGNP SDSEIEAAKP KRSDTLSH