ID   ADIY_ECOLI              Reviewed;         253 AA.
AC   P33234; Q2M6I8;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=HTH-type transcriptional regulator AdiY;
GN   Name=adiY; OrderedLocusNames=b4116, JW4077;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Stim K.P., Bennett G.N.;
RL   Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   INDUCTION, OPERON, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12;
RX   PubMed=12867448; DOI=10.1128/jb.185.15.4402-4409.2003;
RA   Gong S., Richard H., Foster J.W.;
RT   "YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-
RT   dependent acid resistance in Escherichia coli.";
RL   J. Bacteriol. 185:4402-4409(2003).
CC   -!- INDUCTION: By acidic conditions. Forms an operon with upstream adiA but
CC       not downstream adiC. {ECO:0000269|PubMed:12867448}.
CC   -!- DISRUPTION PHENOTYPE: No change in arginine-dependent acid resistance.
CC       {ECO:0000269|PubMed:12867448}.
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DR   EMBL; U02384; AAB18143.1; -; Unassigned_DNA.
DR   EMBL; U14003; AAA97016.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77077.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78118.1; -; Genomic_DNA.
DR   PIR; S56345; S56345.
DR   RefSeq; NP_418540.1; NC_000913.3.
DR   RefSeq; WP_001217060.1; NZ_SSZK01000018.1.
DR   AlphaFoldDB; P33234; -.
DR   SMR; P33234; -.
DR   BioGRID; 4263080; 2.
DR   IntAct; P33234; 2.
DR   STRING; 511145.b4116; -.
DR   PaxDb; P33234; -.
DR   PRIDE; P33234; -.
DR   EnsemblBacteria; AAC77077; AAC77077; b4116.
DR   EnsemblBacteria; BAE78118; BAE78118; BAE78118.
DR   GeneID; 948627; -.
DR   KEGG; ecj:JW4077; -.
DR   KEGG; eco:b4116; -.
DR   PATRIC; fig|1411691.4.peg.2584; -.
DR   EchoBASE; EB1909; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_000445_81_4_6; -.
DR   InParanoid; P33234; -.
DR   OMA; MIIRATQ; -.
DR   PhylomeDB; P33234; -.
DR   BioCyc; EcoCyc:EG11966-MON; -.
DR   PRO; PR:P33234; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..253
FT                   /note="HTH-type transcriptional regulator AdiY"
FT                   /id="PRO_0000194495"
FT   DOMAIN          149..246
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        166..187
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        213..236
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   253 AA;  29007 MW;  6A7DE2B06E60389E CRC64;
     MRICSDQPCI VLLTEKDVWI RVNGKEPISL KANHMALLNC ENNIIDVSSL NNTLVAHISH
     DIIKDYLRFL NKDLSQIPVW QRSATPILTL PCLTPDVFRV AAQHSMMPAE TESEKERTRA
     LLFTVLSRFL DSKKFVSLMM YMLRNCVSDS VYQIIESDIH KDWNLSMVAS CLCLSPSLLK
     KKLKSENTSY SQIITTCRMR YAVNELMMDG KNISQVSQSC GYNSTSYFIS VFKDFYGMTP
     LHYVSQHRER TVA