ID   E18_NPVAC               Reviewed;          90 AA.
AC   P41701;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 2.
DT   23-FEB-2022, entry version 47.
DE   RecName: Full=Protein E18;
DE            Short=E18;
GN   Name=E18;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=8806491; DOI=10.1006/viro.1996.0401;
RA   Braunagel S.C., He H., Ramamurthy P., Summers M.D.;
RT   "Transcription, translation, and cellular localization of three Autographa
RT   californica nuclear polyhedrosis virus structural proteins: ODV-E18, ODV-
RT   E35, and ODV-EC27.";
RL   Virology 222:100-114(1996).
RN   [3]
RP   FUNCTION.
RX   PubMed=18328526; DOI=10.1016/j.virol.2008.01.039;
RA   McCarthy C.B., Theilmann D.A.;
RT   "AcMNPV ac143 (odv-e18) is essential for mediating budded virus production
RT   and is the 30th baculovirus core gene.";
RL   Virology 375:277-291(2008).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20444894; DOI=10.1128/jvi.00040-10;
RA   Wang R., Deng F., Hou D., Zhao Y., Guo L., Wang H., Hu Z.;
RT   "Proteomics of the Autographa californica nucleopolyhedrovirus budded
RT   virions.";
RL   J. Virol. 84:7233-7242(2010).
CC   -!- FUNCTION: Component of the polyhedra envelope. Plays an essential role
CC       in the budded virus production. {ECO:0000269|PubMed:18328526}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:20444894,
CC       ECO:0000269|PubMed:8806491}. Note=Present in both the budded virus (BV)
CC       and the occluded virus (OV). The occluded form allows the virus to be
CC       transmitted from insect to insect through ingestion of contaminated
CC       food while the budded form is responsible for the dissemination of
CC       infection throughout the insect host. {ECO:0000269|PubMed:20444894,
CC       ECO:0000269|PubMed:8806491}.
CC   -!- MISCELLANEOUS: Initially termed ODV-18 since it was found only in
CC       occluded viruses. New approaches also found the protein in budded
CC       virus. It has therefore been renamed to E18.
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DR   EMBL; L22858; AAA66773.1; -; Genomic_DNA.
DR   PIR; A72868; A72868.
DR   RefSeq; NP_054174.1; NC_001623.1.
DR   SMR; P41701; -.
DR   GeneID; 1403976; -.
DR   KEGG; vg:1403976; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019655; Baculo_ODV-E18.
DR   Pfam; PF10717; ODV-E18; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..90
FT                   /note="Protein E18"
FT                   /id="PRO_0000132919"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   90 AA;  9558 MW;  416AA44C4CAF279A CRC64;
     MIYTDPTTGA TTSTDAPSTN YLNRLTPNMF LTILAVVVII ALIIIFVQSS SNGNSSGGNV
     PPNALGGFVN PLNATMRANP FMNTPQRQML