ID   ADK_SCHCO               Reviewed;         344 AA.
AC   O93919;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Adenosine kinase;
DE            EC=2.7.1.20;
GN   Name=ADK;
OS   Schizophyllum commune (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=5334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40;
RA   Hittinger C.T., Copeland T.K., Green A.E., Lilly W.W., Gathman A.C.;
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine + ATP = ADP + AMP + H(+); Xref=Rhea:RHEA:20824,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenosine: step 1/1.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF097765; AAC69199.1; -; mRNA.
DR   AlphaFoldDB; O93919; -.
DR   SMR; O93919; -.
DR   UniPathway; UPA00588; UER00659.
DR   GO; GO:0004001; F:adenosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR001805; Adenokinase.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   PANTHER; PTHR45769; PTHR45769; 1.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00989; ADENOKINASE.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Magnesium; Nucleotide-binding; Purine salvage;
KW   Transferase.
FT   CHAIN           1..344
FT                   /note="Adenosine kinase"
FT                   /id="PRO_0000080060"
FT   ACT_SITE        298
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   344 AA;  36940 MW;  0870350A714E0264 CRC64;
     MSSYKLFCMG NPLLDLQVRD GEKLLEKYGL KSNDAILAEE KHLLLYDEIV KEHEVTYVAG
     GAAQNAARGA AYCLPPKSVV YTGCVGDDDL AEQLKAANKR EGLDEAYLVK KGEKTGACAV
     IITGHDRSLV TTLRAAEKFE QSHLSSEAVA PLVDAVQFYY MEGYFVTHGL ASALELAGKS
     AAKSKCFVLN FSAPFIPQFF MPAIQQLLPY VDIVIANESE AEAWASASGH PAPTDLAAVA
     KSLAMQPKTN PARPRVVIFT HGAEETVVVN SAEPGRVRTF KVDKLAEGEI VDTNGAGDAF
     AGGFLGALVA GRELDDSVEA GHKLAKISIQ QIGPQFKWPK VQIL