ID   ADK_SCHPO               Reviewed;         340 AA.
AC   P78825; Q76PD6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Adenosine kinase;
DE            EC=2.7.1.20;
GN   Name=ado1; ORFNames=SPCC338.14;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine + ATP = ADP + AMP + H(+); Xref=Rhea:RHEA:20824,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenosine: step 1/1.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000305}.
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DR   EMBL; D89173; BAA13835.1; -; mRNA.
DR   EMBL; CU329672; CAA19345.2; -; Genomic_DNA.
DR   PIR; T41729; T41729.
DR   PIR; T42538; T42538.
DR   RefSeq; NP_588154.1; NM_001023143.2.
DR   AlphaFoldDB; P78825; -.
DR   SMR; P78825; -.
DR   BioGRID; 275701; 35.
DR   STRING; 4896.SPCC338.14.1; -.
DR   iPTMnet; P78825; -.
DR   MaxQB; P78825; -.
DR   PaxDb; P78825; -.
DR   PRIDE; P78825; -.
DR   EnsemblFungi; SPCC338.14.1; SPCC338.14.1:pep; SPCC338.14.
DR   GeneID; 2539129; -.
DR   KEGG; spo:SPCC338.14; -.
DR   PomBase; SPCC338.14; ado1.
DR   VEuPathDB; FungiDB:SPCC338.14; -.
DR   eggNOG; KOG2854; Eukaryota.
DR   HOGENOM; CLU_045832_0_0_1; -.
DR   InParanoid; P78825; -.
DR   OMA; APFIAQF; -.
DR   PhylomeDB; P78825; -.
DR   Reactome; R-SPO-74217; Purine salvage.
DR   UniPathway; UPA00588; UER00659.
DR   PRO; PR:P78825; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004001; F:adenosine kinase activity; ISO:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006169; P:adenosine salvage; IC:PomBase.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; ISO:PomBase.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR001805; Adenokinase.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   PANTHER; PTHR45769; PTHR45769; 1.
DR   Pfam; PF00294; PfkB; 1.
DR   PRINTS; PR00989; ADENOKINASE.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Magnesium; Nucleotide-binding; Purine salvage;
KW   Reference proteome; Transferase.
FT   CHAIN           1..340
FT                   /note="Adenosine kinase"
FT                   /id="PRO_0000080061"
FT   ACT_SITE        292
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   340 AA;  36709 MW;  751F55FF68F410EF CRC64;
     MSSYILFGLE NPLLDYYVGG ETATLEKYGL KSNDAVLASE SQMGIYKEPC VSYSAGGAAQ
     NSCRAAQYVL PPNSTVFAGC VGQDKFADML LESNEKAGLR SEFSVDPTTP TGVCAVVLSN
     NNKNRSLCTN LGAANNYKLK DLQQPNVWKF VEEAKVIYVG GFHLTVSPES MLCLAQHANE
     NNKPYIMNLS APFLSQFFKE QMDSVIPYCD YVIGNEAEIL SYGENHGIKS TDVQEIALAL
     SSVEKVNKKR TRVVVITQGA DATIVAKDGK VTTYKPNRVP SEEIVDTNGA GDAFAGGFIA
     ALSQGQGIDY AVTLGHWLGQ ECIKVSGTTL PLPKKQFPLP