E1BS_ADE02
ID E1BS_ADE02 Reviewed; 175 AA.
AC P03247;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=E1B protein, small T-antigen;
DE AltName: Full=E1B 19 kDa protein;
DE Short=E1B-19K;
DE AltName: Full=E1B-175R;
GN Name=E1B;
OS Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus.
OX NCBI_TaxID=10515;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7142161; DOI=10.1016/s0021-9258(18)33473-2;
RA Gingeras T.R., Sciaky D., Gelinas R.E., Bing-Dong J., Yen C.E., Kelly M.M.,
RA Bullock P.A., Parsons B.L., O'Neill K.E., Roberts R.J.;
RT "Nucleotide sequences from the adenovirus-2 genome.";
RL J. Biol. Chem. 257:13475-13491(1982).
RN [2]
RP ALTERNATIVE SPLICING (ISOFORMS E1B-495R AND E1B-155R).
RX PubMed=6323739; DOI=10.1128/jvi.50.2.387-396.1984;
RA Anderson C.W., Schmitt R.C., Smart J.E., Lewis J.B.;
RT "Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and
RT 155 amino acid residues.";
RL J. Virol. 50:387-396(1984).
RN [3]
RP ALTERNATIVE SPLICING (ISOFORMS E1B-495R; E1B-175R; E1B-155R; E1B-92R AND
RP E1B-82R).
RX PubMed=3989911; DOI=10.1128/jvi.54.2.383-391.1985;
RA Virtanen A., Pettersson U.;
RT "Organization of early region 1B of human adenovirus type 2: identification
RT of four differentially spliced mRNAs.";
RL J. Virol. 54:383-391(1985).
RN [4]
RP ALTERNATIVE SPLICING (ISOFORMS E1B-495R; E1B-175R; E1B-155R; E1B-92R AND
RP E1B-82R).
RX PubMed=2960832; DOI=10.1128/jvi.61.12.3879-3888.1987;
RA Lewis J.B., Anderson C.W.;
RT "Identification of adenovirus type 2 early region 1B proteins that share
RT the same amino terminus as do the 495R and 155R proteins.";
RL J. Virol. 61:3879-3888(1987).
CC -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC Without E1B 19K function, virus production is compromised because of
CC premature death of host cell. Interacts with Bax protein in cell
CC lysates (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P03247; O60238: BNIP3L; Xeno; NbExp=7; IntAct=EBI-849856, EBI-849893;
CC -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC Note=Associated with the plasma and nuclear membranes, and with the
CC insoluble nuclear lamina. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=At least five different polypeptides are generated by
CC alternative splicing of a common mRNA precursor.;
CC Name=E1B-175R; Synonyms=E1B-19K;
CC IsoId=P03247-1; Sequence=Displayed;
CC Name=E1B-495R; Synonyms=E1B-55K;
CC IsoId=P03244-1; Sequence=External;
CC Name=E1B-155R; Synonyms=E1B-18K;
CC IsoId=P03244-2; Sequence=External;
CC Name=E1B-92R; Synonyms=E1B-16K;
CC IsoId=P03244-3; Sequence=External;
CC Name=E1B-82R; Synonyms=E1B-15K;
CC IsoId=P03244-4; Sequence=External;
CC -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC {ECO:0000305}.
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DR EMBL; J01917; AAA92200.1; -; Genomic_DNA.
DR PIR; B03814; Q1AD22.
DR RefSeq; AP_000162.1; AC_000007.1. [P03247-1]
DR RefSeq; NP_040510.1; NC_001405.1.
DR IntAct; P03247; 5.
DR MINT; P03247; -.
DR GeneID; 2652981; -.
DR Proteomes; UP000008167; Genome.
DR GO; GO:0044165; C:host cell endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0044199; C:host cell nuclear envelope; IDA:UniProtKB.
DR GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019050; P:suppression by virus of host apoptotic process; IDA:UniProtKB.
DR InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR InterPro; IPR002475; Bcl2-like.
DR Pfam; PF01691; Adeno_E1B_19K; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Early protein; Host cell membrane;
KW Host membrane; Host nucleus; Host-virus interaction;
KW Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW Modulation of host cell apoptosis by virus; Reference proteome.
FT CHAIN 1..175
FT /note="E1B protein, small T-antigen"
FT /id="PRO_0000221710"
FT REGION 147..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 20514 MW; 2FF4279D0CC700B6 CRC64;
MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE FEELLKSCGE
LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK DKWSEETHLS GGYLLDFLAM
HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ QEEARRRRRQ EQSPWNPRAG LDPRE
