ID   E1BS_ADE04              Reviewed;         142 AA.
AC   P10406;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   12-AUG-2020, entry version 78.
DE   RecName: Full=E1B protein, small T-antigen;
DE   AltName: Full=E1B 19 kDa protein;
DE            Short=E1B-19K;
OS   Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus E.
OX   NCBI_TaxID=28280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2947381; DOI=10.1016/0042-6822(86)90204-7;
RA   Tokunaga O., Yaegashi T., Lowe J., Dobbs L., Padmanabhan R.;
RT   "Sequence analysis in the E1 region of adenovirus type 4 DNA.";
RL   Virology 155:418-433(1986).
CC   -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC       induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC       Without E1B 19K function, virus production is compromised because of
CC       premature death of host cell. Interacts with Bax protein in cell
CC       lysates (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC       envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC       Note=Associated with the plasma and nuclear membranes, and with the
CC       insoluble nuclear lamina. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M14918; AAA67093.1; -; Genomic_DNA.
DR   PIR; B25614; WMAD19.
DR   GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR   InterPro; IPR002475; Bcl2-like.
DR   Pfam; PF01691; Adeno_E1B_19K; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Host cell membrane; Host membrane; Host nucleus;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..142
FT                   /note="E1B protein, small T-antigen"
FT                   /id="PRO_0000221711"
SQ   SEQUENCE   142 AA;  16817 MW;  FD917AEFAAA66141 CRC64;
     MEIWTVLEDF HKTRQLLENA SNGVSHLWRF CFGGDLAKLV YRAKQDYREQ FEDILRECPS
     LFDALNLGHQ SHFNQRISRA LDFTTPGRTT AAVAFFAFIF DKWSQETHFS RDYQLDFLAV
     ALWRTWKCQR LNAIPATCRY SR