ID   E1BS_ADE07              Reviewed;         178 AA.
AC   P03248;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   12-AUG-2020, entry version 92.
DE   RecName: Full=E1B protein, small T-antigen;
DE   AltName: Full=E1B 19 kDa protein;
DE            Short=E1B-19K;
OS   Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=10519;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gomen;
RX   PubMed=6290319; DOI=10.1016/0378-1119(82)90112-3;
RA   Dijkema R., Dekker B.M.M., van Ormondt H.;
RT   "Gene organization of the transforming region of adenovirus type 7 DNA.";
RL   Gene 18:143-156(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Grider;
RA   Yoshida K., Fujinaga K.;
RT   "The nucleotide sequence of the transforming HindIII-I.J fragment of
RT   adenovirus type 7 DNA.";
RL   Tumor Res. 19:39-47(1984).
CC   -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC       induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC       Without E1B 19K function, virus production is compromised because of
CC       premature death of host cell. Interacts with Bax protein in cell
CC       lysates (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC       envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC       Note=Associated with the plasma and nuclear membranes, and with the
CC       insoluble nuclear lamina. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC       {ECO:0000305}.
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DR   EMBL; X03000; CAA26762.1; -; Genomic_DNA.
DR   EMBL; M38648; AAA42456.1; -; Genomic_DNA.
DR   PIR; A03815; WMAD21.
DR   RefSeq; AP_000535.1; AC_000018.1.
DR   GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR   InterPro; IPR002475; Bcl2-like.
DR   Pfam; PF01691; Adeno_E1B_19K; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Host cell membrane; Host membrane; Host nucleus;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..178
FT                   /note="E1B protein, small T-antigen"
FT                   /id="PRO_0000221713"
FT   VARIANT         48..49
FT                   /note="RE -> SV (in strain: Grider)"
FT   VARIANT         58
FT                   /note="I -> S (in strain: Grider)"
SQ   SEQUENCE   178 AA;  20575 MW;  FD9D2F814B61D6A7 CRC64;
     MEVWAILEDL RQTRLLLENA SDGVSGLWRF WFGGDLARLV FRIKQDYREE FEKLLDDIPG
     LFEALNLGHQ AHFKEKVLSV LDFSTPGRTA AAVAFLTFIL DKWIRQTHFS KGYVLDFIAA
     ALWRTWKARR MRTILDYWPV QPLGVAGILR HPPTMPAVLQ EEQQEDNPRA GLDPPVEE