E1BS_ADE12
ID E1BS_ADE12 Reviewed; 163 AA.
AC P04492;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 02-JUN-2021, entry version 99.
DE RecName: Full=E1B protein, small T-antigen;
DE AltName: Full=E1B 19 kDa protein;
DE Short=E1B-19K;
OS Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus A.
OX NCBI_TaxID=28282;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7326748; DOI=10.1016/0092-8674(81)90366-4;
RA Bos J.L., Polder L.J., Bernards R., Schrier P.I., van den Elsen P.J.,
RA van der Eb A.J., van Ormondt H.;
RT "The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens
RT starting at different AUG triplets.";
RL Cell 27:121-131(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6275367; DOI=10.1093/nar/9.23.6571;
RA Kimura T., Sawada Y., Shinawawa M., Shimizu Y., Shiroki K., Shimojo H.,
RA Sugisaki H., Takanami M., Uemizu Y., Fujinaga K.;
RT "Nucleotide sequence of the transforming early region E1b of adenovirus
RT type 12 DNA: structure and gene organization, and comparison with those of
RT adenovirus type 5 DNA.";
RL Nucleic Acids Res. 9:6571-6589(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kimura T.;
RT "Structure and sequence analysis of the transforming region E1B of human
RT adenovirus type 12.";
RL Sapporo Igaku Zasshi 52:253-267(1983).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8254750; DOI=10.1128/jvi.68.1.379-389.1994;
RA Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W.;
RT "Nucleotide sequence of human adenovirus type 12 DNA: comparative
RT functional analysis.";
RL J. Virol. 68:379-389(1994).
CC -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC Without E1B 19K function, virus production is compromised because of
CC premature death of host cell. Interacts with Bax protein in cell
CC lysates (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC Note=Associated with the plasma and nuclear membranes, and with the
CC insoluble nuclear lamina. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC {ECO:0000305}.
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DR EMBL; V00004; CAA23406.1; -; Genomic_DNA.
DR EMBL; V00004; CAA23405.1; -; Genomic_DNA.
DR EMBL; V00004; CAA23403.1; -; Genomic_DNA.
DR EMBL; V00004; CAA23404.1; -; Genomic_DNA.
DR EMBL; M55003; AAA42498.1; -; Genomic_DNA.
DR EMBL; X73487; CAA51878.1; -; Genomic_DNA.
DR PIR; A03816; ERAD21.
DR RefSeq; NP_040911.1; NC_001460.1.
DR DIP; DIP-379N; -.
DR DNASU; 1460854; -.
DR GeneID; 1460854; -.
DR Proteomes; UP000004993; Genome.
DR GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR InterPro; IPR002475; Bcl2-like.
DR Pfam; PF01691; Adeno_E1B_19K; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis; Early protein; Host cell membrane; Host membrane; Host nucleus;
KW Host-virus interaction;
KW Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW Modulation of host cell apoptosis by virus.
FT CHAIN 1..163
FT /note="E1B protein, small T-antigen"
FT /id="PRO_0000221714"
SQ SEQUENCE 163 AA; 19125 MW; 216BE9B40857DD54 CRC64;
MELETVLQSF QSVRQLLQYT SKNTSGFWRY LFGSTLSKVV NRVKEDYREE FENILADCPG
LLASLDLCYH LVFQEKVVRS LDFSSVGRTV ASIAFLATIL DKWSEKSHLS WDYMLDYMSM
QLWRAWLKRR VCIYSLARPL TMPPLPTLQE EKEEERNPAV VEK
