E1BS_ADE40
ID E1BS_ADE40 Reviewed; 167 AA.
AC P10543;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=E1B protein, small T-antigen;
DE AltName: Full=E1B 19 kDa protein;
DE Short=E1B-19K;
OS Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F.
OX NCBI_TaxID=28284;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2961652; DOI=10.1016/0378-1119(87)90034-5;
RA van Loon A.E., Ligtenberg M., Reemst A.M.C.B., Sussenbach J.S.,
RA Rozijn T.H.;
RT "Structure and organization of the left-terminal DNA regions of fastidious
RT adenovirus types 40 and 41.";
RL Gene 58:109-126(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2968714; DOI=10.1016/0042-6822(88)90662-9;
RA Ishino M., Ohashi Y., Emoto T., Sawada Y., Fujinaga K.;
RT "Characterization of adenovirus type 40 E1 region.";
RL Virology 165:95-102(1988).
CC -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC Without E1B 19K function, virus production is compromised because of
CC premature death of host cell. Interacts with Bax protein in cell
CC lysates (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC Note=Associated with the plasma and nuclear membranes, and with the
CC insoluble nuclear lamina. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC {ECO:0000305}.
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DR EMBL; M21276; AAA42443.1; -; Genomic_DNA.
DR EMBL; M18288; AAA42448.1; -; Genomic_RNA.
DR EMBL; L19443; AAC13957.1; -; Genomic_DNA.
DR PIR; B29195; WMADP5.
DR RefSeq; NP_040848.1; NC_001454.1.
DR GeneID; 2715936; -.
DR Proteomes; UP000151954; Genome.
DR GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR InterPro; IPR002475; Bcl2-like.
DR Pfam; PF01691; Adeno_E1B_19K; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis; Early protein; Host cell membrane; Host membrane; Host nucleus;
KW Host-virus interaction;
KW Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW Modulation of host cell apoptosis by virus; Reference proteome.
FT CHAIN 1..167
FT /note="E1B protein, small T-antigen"
FT /id="PRO_0000221715"
FT REGION 143..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="T -> A (in Ref. 2; AAA42443)"
FT /evidence="ECO:0000305"
FT CONFLICT 139..140
FT /note="QR -> HG (in Ref. 2; AAA42443)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="Missing (in Ref. 2; AAA42443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 167 AA; 19193 MW; 61B114F0DACA7A9F CRC64;
MELWSELQSY QNLRRLLELA SARTSSCWRI LFGSTLTNVI YRAKEEYSSR FADLLSHNPG
IFASLNLGHH SFFQEIVIRN LDFSSPGRTV SGLAFICFIL DQWSAQTHLS QGYTLDYMAM
ALWRTLLRRK RVLGCLPAQR PHGLDPVQEE EEEEENLRAG LDPSTEL
