ID   E1BS_ADE41              Reviewed;         170 AA.
AC   P10544;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=E1B protein, small T-antigen;
DE   AltName: Full=E1B 19 kDa protein;
DE            Short=E1B-19K;
OS   Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F.
OX   NCBI_TaxID=10524;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2961652; DOI=10.1016/0378-1119(87)90034-5;
RA   van Loon A.E., Ligtenberg M., Reemst A.M.C.B., Sussenbach J.S.,
RA   Rozijn T.H.;
RT   "Structure and organization of the left-terminal DNA regions of fastidious
RT   adenovirus types 40 and 41.";
RL   Gene 58:109-126(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1533079; DOI=10.1016/0042-6822(92)90761-d;
RA   Allard A., Wadell G.;
RT   "The E1B transcription map of the enteric adenovirus type 41.";
RL   Virology 188:319-330(1992).
CC   -!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits apoptosis
CC       induced by TNF or FAS pathways, as well as p53-mediated apoptosis.
CC       Without E1B 19K function, virus production is compromised because of
CC       premature death of host cell. Interacts with Bax protein in cell
CC       lysates (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}. Host nucleus
CC       envelope {ECO:0000250}. Host nucleus lamina {ECO:0000250}.
CC       Note=Associated with the plasma and nuclear membranes, and with the
CC       insoluble nuclear lamina. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
CC       {ECO:0000305}.
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DR   EMBL; M18289; AAA42451.1; -; mRNA.
DR   EMBL; M87544; AAA42474.1; -; Genomic_DNA.
DR   PIR; E27333; WMADF5.
DR   PRIDE; P10544; -.
DR   GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
DR   InterPro; IPR002475; Bcl2-like.
DR   Pfam; PF01691; Adeno_E1B_19K; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Early protein; Host cell membrane; Host membrane; Host nucleus;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein; Membrane;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..170
FT                   /note="E1B protein, small T-antigen"
FT                   /id="PRO_0000221716"
FT   REGION          137..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        157..158
FT                   /note="Missing (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   170 AA;  19618 MW;  7CFAEE2F08BD785D CRC64;
     MEFWSELQSY QSLRRLLELA SARTSSCWRF IFGSTLTNVI YRAKEDYSSR FAELLSFNPG
     IFASLNLGHH SFFQEIVIKN LDFSSPGRTV SGLAFICFIL DQWSAQTHLS EGYTLDYMTM
     ALWRTLLRRK RVLGCSPAQP PHGLDPVREE EEEEEEEENL RAGLDPQTEL