E248R_ASFP4
ID E248R_ASFP4 Reviewed; 248 AA.
AC P0CAB1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Inner membrane protein pE248R;
DE Short=pE248R;
GN OrderedLocusNames=Pret-144;
OS African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS (ASFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Asfuvirales; Asfarviridae; Asfivirus.
OX NCBI_TaxID=561443;
OH NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kutish G.F., Rock D.L.;
RT "African swine fever virus genomes.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for viral fusion with host endosomal membrane and
CC core release. {ECO:0000250|UniProtKB:Q65200}.
CC -!- SUBUNIT: Interacts with A151R. {ECO:0000250|UniProtKB:Q65200}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000250|UniProtKB:Q65200};
CC Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q65200}.
CC Virion membrane {ECO:0000250|UniProtKB:Q65200}. Note=Probably part of
CC the virion inner membrane. {ECO:0000250|UniProtKB:Q65200}.
CC -!- SIMILARITY: Belongs to the asfivirus E248R family. {ECO:0000305}.
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DR EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0CAB1; -.
DR Proteomes; UP000000859; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039641; C:viral inner membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003472; Virion_mem_poxvirus_L1.
DR Pfam; PF02442; L1R_F9L; 1.
PE 3: Inferred from homology;
KW Capsid inner membrane protein; Host membrane; Lipoprotein; Membrane;
KW Myristate; Signal-anchor; Transmembrane; Transmembrane helix; Virion.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..248
FT /note="Inner membrane protein pE248R"
FT /id="PRO_0000373607"
FT TOPO_DOM 2..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q65200"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..248
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q65200"
FT LIPID 2
FT /note="N-myristoyl glycine; by host"
FT /evidence="ECO:0000250|UniProtKB:Q65200"
SQ SEQUENCE 248 AA; 27398 MW; 66A8342F978D2687 CRC64;
MGGSTSKNSF KNTTNIISNS IFNQMQSCIS MLDGKNYIGV FGDGNILNHV FQDLNLSLNT
SCVQKHVNEE NFITNLSNQI TQNLKDQEVA LTQWMDAGTH DQKTDIEENI KVNLTTTLIQ
NCVSSLSGMN VLVVKGNGNI VENATQKQSQ QIISNCLQGS KQAIDTTTGI TNTVNQYSHY
TSKNFFDFIA DAISAVFKNI MVAAVVIVLI IVGFIAVFYF LHSRHRHEEE EEAEPLISNK
VLKNAAVS