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E248R_ASFWA
ID   E248R_ASFWA             Reviewed;         248 AA.
AC   P0CAB2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Inner membrane protein pE248R;
DE            Short=pE248R;
GN   OrderedLocusNames=War-142;
OS   African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561444;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for viral fusion with host endosomal membrane and
CC       core release. {ECO:0000250|UniProtKB:Q65200}.
CC   -!- SUBUNIT: Interacts with A151R. {ECO:0000250|UniProtKB:Q65200}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000250|UniProtKB:Q65200};
CC       Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q65200}.
CC       Virion membrane {ECO:0000250|UniProtKB:Q65200}. Note=Probably part of
CC       the virion inner membrane. {ECO:0000250|UniProtKB:Q65200}.
CC   -!- SIMILARITY: Belongs to the asfivirus E248R family. {ECO:0000305}.
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DR   EMBL; AY261366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000858; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039641; C:viral inner membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003472; Virion_mem_poxvirus_L1.
DR   Pfam; PF02442; L1R_F9L; 1.
PE   3: Inferred from homology;
KW   Capsid inner membrane protein; Host membrane; Lipoprotein; Membrane;
KW   Myristate; Signal-anchor; Transmembrane; Transmembrane helix; Virion.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..248
FT                   /note="Inner membrane protein pE248R"
FT                   /id="PRO_0000373608"
FT   TOPO_DOM        2..199
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q65200"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..248
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q65200"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:Q65200"
SQ   SEQUENCE   248 AA;  27434 MW;  E3D076D6F8B8A8A5 CRC64;
     MGGSTSKNSF KNTTNIISNS IFNQMQSCIS MLDGKNYIGV FGDGNILNHV FQDLNLSLDT
     SCVQKHVNKE NFITNLSNQI TQNLKDQEVA LTQWMDAGHH DQKTDIEENI KVNLTTTLIQ
     NCVSSLSGMN VLVVKGNGNI VENATQKQSQ QIISNCLQGS KQAIDTTTGI TNTVNQYSHY
     TSKNFFDFIA DAISAVFKNI MVAAVVIVLI IVGFIAVFYF LHSRHRHEEE EEAEPLISNK
     VLKNAAVS
 
 
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