ID   E25_NPVAC               Reviewed;         228 AA.
AC   P41483;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   23-FEB-2022, entry version 68.
DE   RecName: Full=Virus envelope protein E25;
DE            Short=Protein E25;
DE   AltName: Full=Virus envelope protein AC94;
GN   Name=P25;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=8317143; DOI=10.1016/0168-1702(93)90132-7;
RA   Goh D.K.;
RT   "Identification and immunocharacterization of a 25K structural protein in
RT   Autographa californica nuclear polyhedrosis virus (AcMNPV).";
RL   Virus Res. 28:141-152(1993).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=9108103; DOI=10.1073/pnas.94.8.4050;
RA   Hong T., Summers M.D., Braunagel S.C.;
RT   "N-terminal sequences from Autographa californica nuclear polyhedrosis
RT   virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct
RT   reporter proteins to the nuclear envelope, intranuclear microvesicles and
RT   the envelope of occlusion derived virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:4050-4055(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=22218963; DOI=10.1007/s00705-011-1211-9;
RA   Chen L., Hu X., Xiang X., Yu S., Yang R., Wu X.;
RT   "Autographa californica multiple nucleopolyhedrovirus odv-e25 (Ac94) is
RT   required for budded virus infectivity and occlusion-derived virus
RT   formation.";
RL   Arch. Virol. 157:617-625(2012).
RN   [5]
RP   INDUCTION.
RX   PubMed=24027316; DOI=10.1128/jvi.02112-13;
RA   Zhu M., Wang J., Deng R., Xiong P., Liang H., Wang X.;
RT   "A microRNA encoded by Autographa californica nucleopolyhedrovirus
RT   regulates expression of viral gene ODV-E25.";
RL   J. Virol. 87:13029-13034(2013).
CC   -!- FUNCTION: Plays a role in the production of infectious budded virion
CC       (BV) and occlusion-derived virion (ODV) formation.
CC       {ECO:0000269|PubMed:22218963}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:9108103}.
CC       Host nucleus {ECO:0000269|PubMed:9108103}. Note=Associated with the
CC       envelopes of virions present in the nucleus of infected cells, with the
CC       envelopes of virions in the process of being occluded and fully
CC       occluded virions. {ECO:0000269|PubMed:9108103}.
CC   -!- DEVELOPMENTAL STAGE: First appears after 18 hours of infection.
CC   -!- INDUCTION: A microRNA encoded by the virus, AcMNPV-miR-1, matches the
CC       E25 gene and down-regulates its mRNA expression which presumably favors
CC       occlusion-derived virions over budded virions.
CC       {ECO:0000269|PubMed:24027316}.
CC   -!- SIMILARITY: Belongs to the baculoviridae p25 family. {ECO:0000305}.
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DR   EMBL; L22858; AAA66724.1; -; Genomic_DNA.
DR   PIR; G72861; G72861.
DR   RefSeq; NP_054124.1; NC_001623.1.
DR   GeneID; 1403927; -.
DR   KEGG; vg:1403927; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IDA:UniProtKB.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007938; Baculo_ODV-E25.
DR   Pfam; PF05274; Baculo_E25; 1.
PE   2: Evidence at transcript level;
KW   Host nucleus; Membrane; Reference proteome; Virion.
FT   CHAIN           1..228
FT                   /note="Virus envelope protein E25"
FT                   /id="PRO_0000132892"
SQ   SEQUENCE   228 AA;  25526 MW;  61F034CA4A6DD388 CRC64;
     MWGIVLLIVL LILFYLYWTN ALNFNSLTES SPSLGQSSDS VELDENKQLN VKLNNGRVAN
     LRIAHGDNKL SQVYIAEKPL SIDDIVKEGS NKVGTNSVFL GTVYDYGIKS PNAASTSSNV
     TMTRGAANFD IKEFKSMFIV FKGVTPTKTV EDNGMLRFEV DNMIVCLIDP NTAPLSEREV
     RELRKSNCTL VYTRNAAAQQ VLLENNFTVI NAEQTAYLKN YKSYREMN