E26_NPVAC
ID E26_NPVAC Reviewed; 225 AA.
AC P12827;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 29-SEP-2021, entry version 55.
DE RecName: Full=Protein E26;
DE AltName: Full=Protein AC16;
GN Name=DA26;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E2;
RX PubMed=2826808; DOI=10.1128/jvi.62.2.463-471.1988;
RA Guarino L.A., Summers M.D.;
RT "Functional mapping of Autographa california nuclear polyhedrosis virus
RT genes required for late gene expression.";
RL J. Virol. 62:463-471(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=L1;
RX PubMed=2189022; DOI=10.1099/0022-1317-71-5-1029;
RA O'Reilly D.R., Passarelli A.L., Goldman I.F., Miller L.K.;
RT "Characterization of the DA26 gene in a hypervariable region of the
RT Autographa californica nuclear polyhedrosis virus genome.";
RL J. Gen. Virol. 71:1029-1037(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E2;
RX PubMed=1333113; DOI=10.1016/0042-6822(92)90281-s;
RA Braunagel S.C., Daniel K.D., Reilly L.M., Guarino L.A., Hong T.,
RA Summers M.D.;
RT "Sequence, genomic organization of the EcoRI-A fragment of Autographa
RT californica nuclear polyhedrosis virus, and identification of a viral-
RT encoded protein resembling the outer capsid protein VP8 of rotavirus.";
RL Virology 191:1003-1008(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [5]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH FP25K.
RX PubMed=9448690; DOI=10.1006/viro.1997.8903;
RA Beniya H., Braunagel S.C., Summers M.D.;
RT "Autographa californica nuclear polyhedrosis virus: subcellular
RT localization and protein trafficking of BV/ODV-E26 to intranuclear
RT membranes and viral envelopes.";
RL Virology 240:64-75(1998).
RN [6]
RP INTERACTION WITH FP25K.
RX PubMed=15150405; DOI=10.1073/pnas.0402727101;
RA Braunagel S.C., Williamson S.T., Saksena S., Zhong Z., Russell W.K.,
RA Russell D.H., Summers M.D.;
RT "Trafficking of ODV-E66 is mediated via a sorting motif and other viral
RT proteins: facilitated trafficking to the inner nuclear membrane.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:8372-8377(2004).
RN [7]
RP FUNCTION, PALMITOYLATION, AND SUBCELLULAR LOCATION.
RX PubMed=17169392; DOI=10.1016/j.virol.2006.11.007;
RA Burks J.K., Summers M.D., Braunagel S.C.;
RT "BV/ODV-E26: a palmitoylated, multifunctional structural protein of
RT Autographa californica nucleopolyhedrovirus.";
RL Virology 361:194-203(2007).
RN [8]
RP FUNCTION, AND INTERACTION WITH IE0 AND IE1.
RX PubMed=19150105; DOI=10.1016/j.virol.2008.12.020;
RA Nie Y., Fang M., Theilmann D.A.;
RT "AcMNPV AC16 (DA26, BV/ODV-E26) regulates the levels of IE0 and IE1 and
RT binds to both proteins via a domain located within the acidic
RT transcriptional activation domain.";
RL Virology 385:484-495(2009).
RN [9]
RP FUNCTION, INTERACTION WITH FP25K AND HOST IMPORTIN ALPHA-16, AND
RP SUBCELLULAR LOCATION.
RX PubMed=19019955; DOI=10.1128/jvi.01661-08;
RA Braunagel S.C., Cox V., Summers M.D.;
RT "Baculovirus data suggest a common but multifaceted pathway for sorting
RT proteins to the inner nuclear membrane.";
RL J. Virol. 83:1280-1288(2009).
CC -!- FUNCTION: Plays a role in the sorting of ODV envelope proteins to the
CC host inner nuclear membrane. May facilitate the fusion and release of
CC nucleocapsids into the cytoplasm. Modulates the expression levels of
CC IE0 and IE1. {ECO:0000269|PubMed:17169392, ECO:0000269|PubMed:19019955,
CC ECO:0000269|PubMed:19150105}.
CC -!- SUBUNIT: Interacts with proteins IE0 and IE1. Interacts with protein
CC FP25K. Interacts with host importin alpha-16.
CC {ECO:0000269|PubMed:15150405, ECO:0000269|PubMed:19019955,
CC ECO:0000269|PubMed:19150105, ECO:0000269|PubMed:9448690}.
CC -!- SUBCELLULAR LOCATION: Host nucleus inner membrane
CC {ECO:0000269|PubMed:17169392, ECO:0000269|PubMed:9448690}. Virion
CC {ECO:0000269|PubMed:9448690}. Host cytoplasm
CC {ECO:0000269|PubMed:17169392, ECO:0000269|PubMed:9448690}. Host nucleus
CC {ECO:0000269|PubMed:17169392}. Note=Early in infection, localizes both
CC in the host nucleus and cytoplasm while later in infection localizes in
CC viral-induced microvesicles within the host nucleus.
CC {ECO:0000269|PubMed:17169392}.
CC -!- PTM: Palmitoylated. {ECO:0000269|PubMed:17169392}.
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DR EMBL; M22619; AAA69846.1; -; Genomic_DNA.
DR EMBL; M18857; AAA66808.1; -; Genomic_DNA.
DR EMBL; M96361; AAA66786.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66646.1; -; Genomic_DNA.
DR PIR; A29891; WMNV29.
DR RefSeq; NP_054045.1; NC_001623.1.
DR SMR; P12827; -.
DR GeneID; 1403848; -.
DR KEGG; vg:1403848; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR021286; Baculovirus_E26.
DR Pfam; PF11050; Viral_env_E26; 1.
PE 1: Evidence at protein level;
KW Early protein; Host cytoplasm; Host membrane; Host nucleus; Lipoprotein;
KW Membrane; Palmitate; Reference proteome; Virion.
FT CHAIN 1..225
FT /note="Protein E26"
FT /id="PRO_0000132857"
SQ SEQUENCE 225 AA; 25910 MW; D27965D85B2C7980 CRC64;
MESVQTRLCA SSNQFAPFKK RQLAVPVGSV NSLTHTITST TVTSVIPKNY QEKRQKICHI
ISSLRNTHLN FNKIQSVHKK KLRHLQNLLR KKNEIIAELV RKLESAQKKT THRNISKPAH
WKYFGVVRCD NTIRTIIGNE KFVRRRLAEL CTLYNAEYVF CQARADGDKD RQALASLLTA
AFGSRVIVYE NSRRFEFINP DEIASGKRLI IKHLQDESQS DINAY
