ID   E27_NPVAC               Reviewed;         290 AA.
AC   P41702;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 62.
DE   RecName: Full=Occlusion-derived virus envelope protein E27;
DE            Short=ODV-E27;
GN   Name=E27; ORFNames=ORF144;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E2;
RA   Ramamurthy P., Braunagel S.C., Summers M.D.;
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=8806491; DOI=10.1006/viro.1996.0401;
RA   Braunagel S.C., He H., Ramamurthy P., Summers M.D.;
RT   "Transcription, translation, and cellular localization of three Autographa
RT   californica nuclear polyhedrosis virus structural proteins: ODV-E18, ODV-
RT   E35, and ODV-EC27.";
RL   Virology 222:100-114(1996).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH HOST MUS209; CDC2 AND CDK6.
RX   PubMed=9736714; DOI=10.1073/pnas.95.19.11205;
RA   Belyavskyi M., Braunagel S.C., Summers M.D.;
RT   "The structural protein ODV-EC27 of Autographa californica
RT   nucleopolyhedrovirus is a multifunctional viral cyclin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:11205-11210(1998).
RN   [5]
RP   INTERACTION WITH P78/83 AND C42.
RX   PubMed=11711623; DOI=10.1128/jvi.75.24.12331-12338.2001;
RA   Braunagel S.C., Guidry P.A., Rosas-Acosta G., Engelking L., Summers M.D.;
RT   "Identification of BV/ODV-C42, an Autographa californica
RT   nucleopolyhedrovirus orf101-encoded structural protein detected in
RT   infected-cell complexes with ODV-EC27 and p78/83.";
RL   J. Virol. 75:12331-12338(2001).
CC   -!- FUNCTION: Acts as a cyclin-like protein and plays a role in the
CC       modulation of host cell cycle. May promote G2/S arrest by interacting
CC       with host mus209/PCNA, cdc2 and cdk6. The cell cycle arrest is
CC       characterized by an intact nuclear envelope, concomitant with sustained
CC       activity of host cdc2. However, viral DNA replication still occurs in
CC       the arrested cells. {ECO:0000269|PubMed:9736714}.
CC   -!- SUBUNIT: Interacts with host mus209/PCNA, cdc2 and cdk6. Forms a
CC       complex with proteins C42 and p78/83. {ECO:0000269|PubMed:11711623,
CC       ECO:0000269|PubMed:9736714}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:8806491}.
CC   -!- SIMILARITY: Belongs to the baculoviridae E27 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA03636.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L22858; AAA66774.1; -; Genomic_DNA.
DR   EMBL; U04051; AAA03636.1; ALT_INIT; Unassigned_DNA.
DR   PIR; B72868; B72868.
DR   RefSeq; NP_054175.1; NC_001623.1.
DR   GeneID; 1403977; -.
DR   KEGG; vg:1403977; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR007978; Baculo_ODV-E27.
DR   Pfam; PF05314; Baculo_ODV-E27; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Membrane;
KW   Modulation of host cell cycle by viral cyclin-like protein;
KW   Modulation of host cell cycle by virus; Reference proteome;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..290
FT                   /note="Occlusion-derived virus envelope protein E27"
FT                   /id="PRO_0000132921"
SQ   SEQUENCE   290 AA;  33528 MW;  11725F74BAEB9FC8 CRC64;
     MKRIKCNKVR TVTEIVNSDE KIQKTYELAE FDLKNLSSLE SYETLKIKLA LSKYMAMLST
     LEMTQPLLEI FRNKADTRQI AAVVFSTLAF IHNRFHPLVT NFTNKMEFVV TETNDTSIPG
     EPILFTENEG VLLCSVDRPS IVKMLSREFD TEALVNFEND NCNVRIAKTF GASKRKNTTR
     SDDYESNKQP NYDMDLSDFS ITEVEATQYL TLLLTVEHAY LHYYIFKNYG VFEYCKSLTD
     HSLFTNKLRS TMSTKTSNLL LSKFKFTIED FDKINSNSVT SGFNIYNFNK