ID   E2AB_ECOLX              Reviewed;         123 AA.
AC   P13812;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Heat-labile enterotoxin IIA, B chain;
DE            Short=LT-IIA;
DE   Flags: Precursor;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SA53;
RX   PubMed=2822667; DOI=10.1128/jb.169.11.5180-5187.1987;
RA   Pickett C.L., Weinstein D.L., Holmes R.K.;
RT   "Genetics of type IIa heat-labile enterotoxin of Escherichia coli: operon
RT   fusions, nucleotide sequence, and hybridization studies.";
RL   J. Bacteriol. 169:5180-5187(1987).
CC   -!- FUNCTION: The biological activity of the toxin is produced by the A
CC       chain, which activates intracellular adenyl cyclase.
CC   -!- SUBUNIT: Heterohexamer of one A chain and of five B chains.
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DR   EMBL; JQ031711; AAA24094.1; -; Genomic_DNA.
DR   PIR; B29831; B29831.
DR   RefSeq; WP_000095643.1; NZ_VOCX01000183.1.
DR   AlphaFoldDB; P13812; -.
DR   SMR; P13812; -.
DR   PATRIC; fig|562.7992.peg.3967; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.50; -; 1.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR010503; LT-IIB.
DR   InterPro; IPR038629; LT-IIB_sf.
DR   Pfam; PF06453; LT-IIB; 1.
DR   PIRSF; PIRSF019554; LT-IIB; 1.
DR   SUPFAM; SSF50203; SSF50203; 1.
PE   4: Predicted;
KW   Disulfide bond; Enterotoxin; Signal; Toxin; Virulence.
FT   SIGNAL          1..19
FT   CHAIN           20..123
FT                   /note="Heat-labile enterotoxin IIA, B chain"
FT                   /id="PRO_0000019357"
FT   DISULFID        33..104
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   123 AA;  13361 MW;  65A036ACD362C565 CRC64;
     MSSKKIIGAF VLMTGILSGQ VYAGVSEHFR NICNQTTADI VAGVQLKKYI ADVNTNTRGI
     YVVSNTGGVW YIPGGRDYPD NFLSGEIRKT AMAAILSDTK VNLCAKTSSS PNHIWAMELD
     RES