ADLO1_ARATH
ID ADLO1_ARATH Reviewed; 930 AA.
AC O22161;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protein ARABIDILLO 1;
DE AltName: Full=F-box only protein 5;
GN Name=FBX5; OrderedLocusNames=At2g44900; ORFNames=T13E15.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11077244; DOI=10.1016/s1360-1385(00)01769-6;
RA Xiao W., Jang J.-C.;
RT "F-box proteins in Arabidopsis.";
RL Trends Plant Sci. 5:454-457(2000).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP NUCLEAR LOCALIZATION SIGNAL, AND MUTAGENESIS OF ARG-4; ARG-6; ARG-7 AND
RP LYS-8.
RX PubMed=16434475; DOI=10.1073/pnas.0507575103;
RA Coates J.C., Laplaze L., Haseloff J.;
RT "Armadillo-related proteins promote lateral root development in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:1621-1626(2006).
RN [5]
RP INTERACTION WITH SNL1.
RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA Conlan R.S.;
RT "PAH-domain-specific interactions of the Arabidopsis transcription
RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT EARLY2 Myb-DNA binding factors.";
RL J. Mol. Biol. 395:937-949(2010).
RN [6]
RP INTERACTION WITH MYB53; MYB92 AND MYB93.
RX PubMed=24902892; DOI=10.1111/nph.12879;
RA Gibbs D.J., Voss U., Harding S.A., Fannon J., Moody L.A., Yamada E.,
RA Swarup K., Nibau C., Bassel G.W., Choudhary A., Lavenus J., Bradshaw S.J.,
RA Stekel D.J., Bennett M.J., Coates J.C.;
RT "AtMYB93 is a novel negative regulator of lateral root development in
RT Arabidopsis.";
RL New Phytol. 203:1194-1207(2014).
CC -!- FUNCTION: Promotes lateral root initiation and development,
CC independently of auxin (IAA) and abscisis acid (ABA).
CC {ECO:0000269|PubMed:16434475}.
CC -!- SUBUNIT: Interacts with SNL1 (PubMed:19962994). Interacts with MYB53,
CC MYB92 and MYB93 (PubMed:24902892). {ECO:0000269|PubMed:19962994,
CC ECO:0000269|PubMed:24902892}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16434475}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously, with higher levels in root
CC tip, pericycle and vasculature. {ECO:0000269|PubMed:16434475}.
CC -!- DEVELOPMENTAL STAGE: Present in lateral root primordia.
CC {ECO:0000269|PubMed:16434475}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; AC002388; AAC31834.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10482.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62877.1; -; Genomic_DNA.
DR PIR; T00403; T00403.
DR RefSeq; NP_001325003.1; NM_001337106.1.
DR RefSeq; NP_566029.1; NM_130054.3.
DR AlphaFoldDB; O22161; -.
DR SMR; O22161; -.
DR STRING; 3702.AT2G44900.1; -.
DR PaxDb; O22161; -.
DR PRIDE; O22161; -.
DR ProteomicsDB; 244863; -.
DR EnsemblPlants; AT2G44900.1; AT2G44900.1; AT2G44900.
DR EnsemblPlants; AT2G44900.2; AT2G44900.2; AT2G44900.
DR GeneID; 819099; -.
DR Gramene; AT2G44900.1; AT2G44900.1; AT2G44900.
DR Gramene; AT2G44900.2; AT2G44900.2; AT2G44900.
DR KEGG; ath:AT2G44900; -.
DR Araport; AT2G44900; -.
DR TAIR; locus:2055033; AT2G44900.
DR eggNOG; ENOG502SAGE; Eukaryota.
DR HOGENOM; CLU_018807_0_0_1; -.
DR InParanoid; O22161; -.
DR OMA; DRNREGI; -.
DR OrthoDB; 149274at2759; -.
DR PhylomeDB; O22161; -.
DR PRO; PR:O22161; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22161; baseline and differential.
DR Genevisible; O22161; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0048527; P:lateral root development; IMP:TAIR.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR044583; ARABIDILLO1/2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR46976; PTHR46976; 1.
DR Pfam; PF00514; Arm; 6.
DR SMART; SM00185; ARM; 8.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..930
FT /note="Protein ARABIDILLO 1"
FT /id="PRO_0000273537"
FT DOMAIN 44..90
FT /note="F-box"
FT REPEAT 172..212
FT /note="ARM 1"
FT REPEAT 244..285
FT /note="ARM 2"
FT REPEAT 379..418
FT /note="ARM 3"
FT REPEAT 428..467
FT /note="ARM 4"
FT REPEAT 469..508
FT /note="ARM 5"
FT REPEAT 510..552
FT /note="ARM 6"
FT REPEAT 554..594
FT /note="ARM 7"
FT REPEAT 600..639
FT /note="ARM 8"
FT REPEAT 641..683
FT /note="ARM 9"
FT REPEAT 685..724
FT /note="ARM 10"
FT REPEAT 726..766
FT /note="ARM 11"
FT REPEAT 790..831
FT /note="ARM 12"
FT REPEAT 835..875
FT /note="ARM 13"
FT MOTIF 3..8
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:16434475"
FT MUTAGEN 4
FT /note="R->A: Prevents nuclear localization; when associated
FT with A-6."
FT /evidence="ECO:0000269|PubMed:16434475"
FT MUTAGEN 6
FT /note="R->A: Prevents nuclear localization; when associated
FT with A-4; A-7 or A-8."
FT /evidence="ECO:0000269|PubMed:16434475"
FT MUTAGEN 7
FT /note="R->A: Prevents nuclear localization; when associated
FT with A-6 or A-8."
FT /evidence="ECO:0000269|PubMed:16434475"
FT MUTAGEN 8
FT /note="K->A: Prevents nuclear localization; when associated
FT with A-6 or A-7."
FT /evidence="ECO:0000269|PubMed:16434475"
SQ SEQUENCE 930 AA; 100642 MW; 69140BEF869CDC1F CRC64;
MSRRVRRKLE EEKGKDKVVV LPSYPETSIS NEEDLVAPEL LHGFVDWISL PYDTVLQLFT
CLNYRDRASL ASTCKTWRCL GASSCLWTSL DLRPHKFDAS MAASLASRCV NLHYLRFRGV
ESADSLIHLK ARNLIEVSGD YCKKITDATL SMIVARHEAL ESLQLGPDFC ERITSDAIKA
VAFCCPKLKK LRLSGIRDVT SEAIEALAKH CPQLNDLGFL DCLNIDEEAL GKVVSVRYLS
VAGTSNIKWS IASNNWDKLP KLTGLDVSRT DIGPTAVSRF LTSSQSLKVL CALNCHVLEE
DESLISYNRF KGKVLLALFT NVFDGLASIF ADNTKKPKDI FAYWRELMKT TKDKTINDFI
HWIEWIISHT LLRTAECNPE GLDDFWLNEG AALLLNLMQS SQEDVQERSA TGLATFVVVD
DENASIDCGR AEAVMKDGGI RLLLELAKSW REGLQSEAAK AIANLSVNAN IAKSVAEEGG
IKILAGLAKS MNRLVAEEAA GGLWNLSVGE EHKNAIAQAG GVKALVDLIF RWPNGCDGVL
ERAAGALANL AADDKCSMEV AKAGGVHALV MLARNCKYEG VQEQAARALA NLAAHGDSNN
NNAAVGQEAG ALEALVQLTK SPHEGVRQEA AGALWNLSFD DKNRESISVA GGVEALVALA
QSCSNASTGL QERAAGALWG LSVSEANSVA IGREGGVPPL IALARSEAED VHETAAGALW
NLAFNPGNAL RIVEEGGVPA LVHLCSSSVS KMARFMAALA LAYMFDGRMD EYALMIGTSS
SESTSKNISL DGARNMALKH IEAFVLSFID PHIFESPVVS STPTMLAQVT ERARIQEAGH
LRCSGAEIGR FVTMLRNPDS TLKACAAFAL LQFTIPGGRH AMHHVSLMQN GGESRFLRSA
AASAKTPREA KIFTKILLRN LEHHQAESSI
