ID   ADM1B_XENLA             Reviewed;         404 AA.
AC   Q7ZXD6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Proteasomal ubiquitin receptor ADRM1-B;
GN   Name=adrm1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. Within the complex, functions as a proteasomal ubiquitin
CC       receptor. {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus
CC       {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
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DR   EMBL; BC045042; AAH45042.1; -; mRNA.
DR   EMBL; BC106295; AAI06296.1; -; mRNA.
DR   RefSeq; NP_001079594.1; NM_001086125.1.
DR   RefSeq; XP_018089504.1; XM_018234015.1.
DR   AlphaFoldDB; Q7ZXD6; -.
DR   SMR; Q7ZXD6; -.
DR   DNASU; 379281; -.
DR   GeneID; 379281; -.
DR   KEGG; xla:379281; -.
DR   CTD; 379281; -.
DR   Xenbase; XB-GENE-865867; adrm1.L.
DR   OMA; PEPGYIY; -.
DR   OrthoDB; 1479349at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379281; Expressed in muscle tissue and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR   GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR   Gene3D; 1.10.2020.20; -; 1.
DR   Gene3D; 2.30.29.70; -; 1.
DR   InterPro; IPR044867; DEUBAD_dom.
DR   InterPro; IPR006773; Rpn13/ADRM1.
DR   InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR   InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR   InterPro; IPR032368; RPN13_DEUBAD.
DR   InterPro; IPR038108; RPN13_DEUBAD_sf.
DR   PANTHER; PTHR12225; PTHR12225; 1.
DR   Pfam; PF04683; Proteasom_Rpn13; 1.
DR   Pfam; PF16550; RPN13_C; 1.
DR   PROSITE; PS51916; DEUBAD; 1.
DR   PROSITE; PS51917; PRU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Proteasomal ubiquitin receptor ADRM1-B"
FT                   /id="PRO_0000286073"
FT   DOMAIN          17..130
FT                   /note="Pru"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01265"
FT   DOMAIN          278..390
FT                   /note="DEUBAD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT   REGION          128..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..404
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  42047 MW;  264BEF91A087A314 CRC64;
     MSSGALFPSL VPGSRGSSSK YLVEFRAGKM SLKGSTVTPD KRKGLVYIQQ TDDSLIHFCW
     KDRTSGSVDD DLIIFPDDCE FKRVSQCTTG RVYVLKFKAG SKRLFFWMQE PKTDKDEEHC
     RKVNEYLNNP PMPGALGGSG SGSHELSALG GEGGLQSLLG NMSHNQLMQL IGPTGLGGLG
     GLGALTGPGL ASLLGSGGPT TSSSSSSSRS QSAAVTPSST TSSTRTTSAP VAPAAAPATT
     PSPAVSSNDG ASAATSPTQA IQLSDLQNIL ATMNVPATGE GGQQVDLASV LTPEIMAPIL
     ANAEVQERLM PYLPSGESLP QTADEIQNTL TSPQFQQALS MFSAALASGQ LGPLMSQFGL
     PADAVDAANK GDIEAFAKAM QSTSSQKERE SSEKKEEEED MSLD