ID   E2_VACCC                Reviewed;         737 AA.
AC   P21080;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein E2;
GN   ORFNames=E2L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- SIMILARITY: Belongs to the poxviridae E2 protein family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48039.1; -; Genomic_DNA.
DR   PIR; F42508; F42508.
DR   SMR; P21080; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR007585; Poxvirus_E2.
DR   InterPro; IPR021155; Poxvirus_E2/O1.
DR   Pfam; PF04497; Pox_E2-like; 1.
DR   PIRSF; PIRSF015692; VAC_E2L; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..737
FT                   /note="Protein E2"
FT                   /id="PRO_0000099443"
SQ   SEQUENCE   737 AA;  85917 MW;  4D8EB8A1BFC2E2F4 CRC64;
     MISVTDIRRA FLDNECHTIT KAFGYLHEDN AIALIKIGFH PTYLPKVLYN NVVEFVPEKL
     YLFKPRTVAP LDLISTITKL KNVDKFASHI NYHKNSILIT GDKSLIVKCM PYMIISDDDI
     RFIREQFVGT NSIEYILSFI NKESIYRMSY QFSENEIVTI INRDHFMYEP IYEHQVLDSD
     FLKTMLDRYG IVPINSGIID ELCPEAIIEI LMAVVRPRDA IRFLDIVNKN QLTEDSVKNY
     IINDIRRGKI DYYIPYVEDF LEDRTEDLGI YANIFFEDAI DITKLDITKT ELEHISKYMN
     YYTTYIDHIV NIILQNNYID ILASIIDYVQ DVLTEELCIR IVCESTNPVP VTSLPIHSTL
     VMVMCIQMKY VDIVEFLDEI DIDTLIEKGA DPITEYTFTT RWYNKHNDLI TLYIKKYGFC
     PMMMKRLMFE YPLTKEASDH LLKTMDENRG AIMFFPRTIC TLPYLLCCNY KLIQKPIPFK
     EENRNIVYKK NNRVLCFDSL ENSAFKSLIK IDSIPGLKTY NMKDITYEKS NNIICVRFIP
     QESIHNEERR IKLQLFDIAR LASYGLYYIP SRYLSSWTPV VNMIEGREYT NPQKIECLVI
     LDLFSEEFIE YQNLGNAVSN KYELEYTISN YQAAINCLMS TLLIYLVLGS IRSISKTEDF
     VLSILNIFYK GLKINELLSE PVSGVCIELN KIKDRASSGD SSFIFLKKNE LSKTLSLCEK
     VCVETILDNN QSFKSSK