ID   E2_VAR67                Reviewed;         737 AA.
AC   P33862;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein E2;
GN   ORFNames=E2L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- SIMILARITY: Belongs to the poxviridae E2 protein family. {ECO:0000305}.
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DR   EMBL; X69198; CAA48984.1; -; Genomic_DNA.
DR   PIR; E36841; E36841.
DR   RefSeq; NP_042087.1; NC_001611.1.
DR   SMR; P33862; -.
DR   GeneID; 1486408; -.
DR   KEGG; vg:1486408; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR007585; Poxvirus_E2.
DR   InterPro; IPR021155; Poxvirus_E2/O1.
DR   Pfam; PF04497; Pox_E2-like; 1.
DR   PIRSF; PIRSF015692; VAC_E2L; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..737
FT                   /note="Protein E2"
FT                   /id="PRO_0000099445"
SQ   SEQUENCE   737 AA;  85958 MW;  F8CA3A5A6EFA17E0 CRC64;
     MISVTDIRRA FLDNECHTIT KAFGYLHEDK AIALIKIGFH PTYLPKVLYN NVVEFVPEKL
     YLFKPRTVAP LDLISTITKL KNVDKFASHI NYHKNSILIT GDKSLIVKCM PYMIISDDDI
     RFIREQFVGT NSIEYILSFI NKESIYRMSY QFSENEIVTI INRDHFMYEP IYEHQVLDSD
     FLKTMLDKYG IVPINSGIID ELYPEAIIEI LMAVVRPRDA IRFLDIVNKN QLTEDSVKNY
     IINDIRRGKI DYYIPYVEDF LEDRTEDLGI YANIFFEDAI DITKLDITKT ELEHISKYIN
     YYTTYIDHIV NIILQNNYID ILASIIDYVQ DVLTEELCIR IVCESTNPVP VTSLPIHSTL
     VMVMCIQMKY VDIVEFLDEI DIDTLIEKGA DPITEYTFTT RWYNKHNDLI TLYIKKYGFC
     PMMMKRLMFE YPLTKEASDH LLKTMDENRG AIMFFPRTIC TLPYLLCCNY KLIQKPIPFK
     EENRNIVYKK TNRVLCFDLL ENSAFKSLIK IDSIPGLKTY NMKDITYEKS NNIICVRFIP
     QESIHNEERR IKLQLFDIAR LASYGLYYIP SRYLSSWTPV VNMIEGREYT NPQKIECLVI
     LDLFSEEFIE YQNLGNAVSN KYELEYTISN YQAAINCLMS TLLIYLVLGS IRSISKTENF
     VLSILNIFYK GLKINELLSE PVSGVCIELD KIKDRASSGD SSFIFLKKNE LSKTLSLCEK
     VCVETILDNN QSFKSSK