ADM2_MOUSE
ID ADM2_MOUSE Reviewed; 150 AA.
AC Q7TNK8; Q4VAE1;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein ADM2;
DE AltName: Full=Intermedin;
DE Contains:
DE RecName: Full=Adrenomedullin-2;
DE Short=AM2;
DE AltName: Full=Intermedin-long;
DE Short=IMDL;
DE Contains:
DE RecName: Full=Intermedin-short;
DE Short=IMDS;
DE Flags: Precursor;
GN Name=Adm2; Synonyms=Am2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=14615490; DOI=10.1074/jbc.m305332200;
RA Roh J., Chang C.L., Bhalla A., Klein C., Hsu S.Y.T.;
RT "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide
RT acting through the calcitonin receptor-like receptor/receptor activity-
RT modifying protein receptor complexes.";
RL J. Biol. Chem. 279:7264-7274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=14706825; DOI=10.1016/s0014-5793(03)01368-1;
RA Takei Y., Inoue K., Ogoshi M., Kawahara T., Bannai H., Miyano S.;
RT "Identification of novel adrenomedullin in mammals: a potent cardiovascular
RT and renal regulator.";
RL FEBS Lett. 556:53-58(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: [Adrenomedullin-2]: May play a role as physiological
CC regulators of gastrointestinal, cardiovascular bioactivities mediated
CC by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent
CC pathway. {ECO:0000269|PubMed:14615490, ECO:0000269|PubMed:14706825}.
CC -!- FUNCTION: [Intermedin-short]: May play a role as physiological
CC regulators of gastrointestinal, cardiovascular bioactivities mediated
CC by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent
CC pathway. {ECO:0000269|PubMed:14615490, ECO:0000269|PubMed:14706825}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: High expression detected in the submaxillary gland,
CC kidney, stomach, and mesentery, followed by the pituitary, lung,
CC pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the
CC intermediate lobe of the pituitary, with sporadic in the anterior lobe.
CC {ECO:0000269|PubMed:14615490, ECO:0000269|PubMed:14706825}.
CC -!- SIMILARITY: Belongs to the adrenomedullin family. {ECO:0000305}.
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DR EMBL; AF529212; AAQ09099.1; -; mRNA.
DR EMBL; AB121035; BAD07412.1; -; mRNA.
DR EMBL; BC096428; AAH96428.1; -; mRNA.
DR CCDS; CCDS27744.1; -.
DR RefSeq; NP_891558.1; NM_182928.5.
DR AlphaFoldDB; Q7TNK8; -.
DR SMR; Q7TNK8; -.
DR STRING; 10090.ENSMUSP00000064761; -.
DR iPTMnet; Q7TNK8; -.
DR PhosphoSitePlus; Q7TNK8; -.
DR PaxDb; Q7TNK8; -.
DR PRIDE; Q7TNK8; -.
DR ProteomicsDB; 285728; -.
DR Antibodypedia; 52597; 171 antibodies from 19 providers.
DR Ensembl; ENSMUST00000066991; ENSMUSP00000064761; ENSMUSG00000054136.
DR GeneID; 223780; -.
DR KEGG; mmu:223780; -.
DR UCSC; uc007xgb.2; mouse.
DR CTD; 79924; -.
DR MGI; MGI:2675256; Adm2.
DR VEuPathDB; HostDB:ENSMUSG00000054136; -.
DR eggNOG; ENOG502S7F2; Eukaryota.
DR GeneTree; ENSGT00940000154380; -.
DR HOGENOM; CLU_134508_0_0_1; -.
DR InParanoid; Q7TNK8; -.
DR OMA; RLWQLVR; -.
DR OrthoDB; 1381783at2759; -.
DR PhylomeDB; Q7TNK8; -.
DR TreeFam; TF338591; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
DR BioGRID-ORCS; 223780; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q7TNK8; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q7TNK8; protein.
DR Bgee; ENSMUSG00000054136; Expressed in animal zygote and 25 other tissues.
DR Genevisible; Q7TNK8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; ISO:MGI.
DR GO; GO:0007586; P:digestion; ISO:MGI.
DR GO; GO:0007631; P:feeding behavior; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
DR GO; GO:0003073; P:regulation of systemic arterial blood pressure; IBA:GO_Central.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250|UniProtKB:P61312"
FT PROPEP 26..100
FT /evidence="ECO:0000250"
FT /id="PRO_0000000980"
FT PEPTIDE 103..149
FT /note="Adrenomedullin-2"
FT /evidence="ECO:0000250"
FT /id="PRO_0000000981"
FT PEPTIDE 110..149
FT /note="Intermedin-short"
FT /evidence="ECO:0000255"
FT /id="PRO_0000000982"
FT REGION 28..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 149
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT DISULFID 112..117
FT /evidence="ECO:0000250"
SQ SEQUENCE 150 AA; 16188 MW; 2BFF392BFBFDEBBA CRC64;
MAQLLMVTVT LGCISLLYLL PGTLSGSLGK GLRHSRPREP PAKIPSSNLQ PGHPSLQPVV
WKSRRHAPQP QGRGNRALAM VHLPQGGGSR HPGPQRPTGS RRPHAQLLRV GCVLGTCQVQ
NLSHRLWQLV RPAGRRDSAP VDPSSPHSYG
