ID   E310_ADE03              Reviewed;          91 AA.
AC   P11318;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-DEC-2020, entry version 69.
DE   RecName: Full=Early E3B 10.4 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=45659;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3582978; DOI=10.1016/0378-1119(86)90322-7;
RA   Signaes C., Akusjaervi G., Pettersson U.;
RT   "Region E3 of human adenoviruses; differences between the oncogenic
RT   adenovirus-3 and the non-oncogenic adenovirus-2.";
RL   Gene 50:173-184(1986).
RN   [2]
RP   IDENTIFICATION OF PROTEIN.
RX   PubMed=2296083; DOI=10.1128/jvi.64.2.794-801.1990;
RA   Tollefson A.E., Krajsci P., Yei S., Carlin C.R., Wold W.S.M.;
RT   "A 10,400-molecular-weight membrane protein is coded by region E3 of
RT   adenovirus.";
RL   J. Virol. 64:794-801(1990).
CC   -!- FUNCTION: Down-regulates the EGF receptor.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3B family. {ECO:0000305}.
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DR   EMBL; M15952; AAA42487.1; -; Genomic_DNA.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005041; Adeno_E3B.
DR   Pfam; PF03376; Adeno_E3B; 1.
PE   3: Inferred from homology;
KW   Early protein; Host endoplasmic reticulum; Host membrane; Membrane; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..91
FT                   /note="Early E3B 10.4 kDa protein"
FT                   /id="PRO_0000036472"
FT   TOPO_DOM        23..34
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10356 MW;  10F5281008DB2C41 CRC64;
     MIPRNFFFTI LICPFNVCAT FTAVATASPD CIGPFASYAL FAFVTCICVC SIVCLVINFF
     QLVDWIFVRI AYLRHHPEYR NQNVAALLRL I