ID   E310_ADE05              Reviewed;          91 AA.
AC   P06497;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 87.
DE   RecName: Full=Early E3B 10.4 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=28285;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2981456; DOI=10.1016/0042-6822(85)90443-x;
RA   Cladaras C., Wold W.S.M.;
RT   "DNA sequence of the early E3 transcription unit of adenovirus 5.";
RL   Virology 140:28-43(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1727603; DOI=10.1016/0042-6822(92)90082-z;
RA   Chroboczek J., Bieber F., Jacrot B.;
RT   "The sequence of the genome of adenovirus type 5 and its comparison with
RT   the genome of adenovirus type 2.";
RL   Virology 186:280-285(1992).
CC   -!- FUNCTION: Down-regulates the EGF receptor.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3B family. {ECO:0000305}.
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DR   EMBL; M73260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X03002; CAA26785.1; -; Genomic_DNA.
DR   RefSeq; AP_000222.1; AC_000008.1.
DR   SMR; P06497; -.
DR   Proteomes; UP000004992; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005041; Adeno_E3B.
DR   Pfam; PF03376; Adeno_E3B; 1.
PE   3: Inferred from homology;
KW   Early protein; Host endoplasmic reticulum; Host membrane; Membrane; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..91
FT                   /note="Early E3B 10.4 kDa protein"
FT                   /id="PRO_0000036473"
FT   TOPO_DOM        23..34
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10405 MW;  E100F4DE013DF107 CRC64;
     MIPRVFILLT LVALFCACST LAAVSHIEVD CIPAFTVYLL YGFVTLTLIC SLITVVIAFI
     QCIDWVCVRF AYLRHHPQYR DRTIAELLRI L