ID   E310_ADE06              Reviewed;          91 AA.
AC   O55654;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Early E3B 10.4 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=10534;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D.,
RA   Bauer U., Flunker G., Seidel W.;
RT   "Sequence analysis of group C human adenoviruses type 1 and 6 for five
RT   genes of region E3.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Down-regulates the EGF receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-pass
CC       type I membrane protein.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3B family. {ECO:0000305}.
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DR   EMBL; Y16037; CAA75992.1; -; Genomic_DNA.
DR   SMR; O55654; -.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005041; Adeno_E3B.
DR   Pfam; PF03376; Adeno_E3B; 1.
PE   3: Inferred from homology;
KW   Early protein; Host endoplasmic reticulum; Host membrane; Membrane; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..91
FT                   /note="Early E3B 10.4 kDa protein"
FT                   /id="PRO_0000036471"
FT   TOPO_DOM        23..34
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10389 MW;  933606E36BBCE9EE CRC64;
     MIPRVLILLT LVALFCACST LAAVAHIEVD CIPPFTVYLL YGFVTLILIC SLVTVVIAFI
     QFIDWICVRI AYLRHHPQYR DRTIADLLRI L