ID   E310_ADE07              Reviewed;          91 AA.
AC   P15134;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   12-AUG-2020, entry version 73.
DE   RecName: Full=Early E3B 10.4 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=10519;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gomen;
RX   PubMed=2849239;
RA   Hong J.S., Mullis K.G., Engler J.A.;
RT   "Characterization of the early region 3 and fiber genes of Ad7.";
RL   Virology 167:545-553(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=87-922;
RA   Kajon A.E., Wadell G.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=bal;
RA   Inada T., Mukoyama A., Yamadera S., Hashido M., Inoue S.;
RT   "Epidemiology and genomic analysis of hexon, fiber and E3 region genes of
RT   adenovirus type 7 in Japan.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Down-regulates the EGF receptor.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3B family. {ECO:0000305}.
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DR   EMBL; M23696; AAA53251.1; -; Genomic_DNA.
DR   EMBL; Z48954; CAA88813.1; -; Genomic_DNA.
DR   EMBL; AF104384; AAF14145.1; -; Genomic_DNA.
DR   PIR; G31830; ERAD77.
DR   RefSeq; AP_000560.1; AC_000018.1.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005041; Adeno_E3B.
DR   Pfam; PF03376; Adeno_E3B; 1.
PE   3: Inferred from homology;
KW   Early protein; Host endoplasmic reticulum; Host membrane; Membrane; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..91
FT                   /note="Early E3B 10.4 kDa protein"
FT                   /id="PRO_0000036474"
FT   TOPO_DOM        23..34
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10330 MW;  0C85346008CE2C54 CRC64;
     MIPRNFFFTI LICAFNVCAT FTAVATASPD CIGPFASYAL FAFVTCICVC SIVCLVINFF
     QLVDWIFVRI AYLRHHPEYR NQNVAALLRL I