ID   E310_ADE12              Reviewed;          91 AA.
AC   P36705;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 71.
DE   RecName: Full=Early E3B 10.4 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus A.
OX   NCBI_TaxID=28282;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8254750; DOI=10.1128/jvi.68.1.379-389.1994;
RA   Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W.;
RT   "Nucleotide sequence of human adenovirus type 12 DNA: comparative
RT   functional analysis.";
RL   J. Virol. 68:379-389(1994).
CC   -!- FUNCTION: Down-regulates the EGF receptor.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3B family. {ECO:0000305}.
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DR   EMBL; X73487; CAA51897.1; -; Genomic_DNA.
DR   PIR; S33948; S33948.
DR   RefSeq; NP_040930.1; NC_001460.1.
DR   SMR; P36705; -.
DR   DNASU; 1460862; -.
DR   GeneID; 1460862; -.
DR   Proteomes; UP000004993; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR005041; Adeno_E3B.
DR   Pfam; PF03376; Adeno_E3B; 1.
PE   3: Inferred from homology;
KW   Early protein; Host endoplasmic reticulum; Host membrane; Membrane; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..91
FT                   /note="Early E3B 10.4 kDa protein"
FT                   /id="PRO_0000036475"
FT   TOPO_DOM        22..33
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10425 MW;  8877D1C6F505849F CRC64;
     MVTVLLIFLC LPVIFSSSTF AAVSDLDPEC LAPFAVYLIF TFVTATCVCS IITLLITSLQ
     FFDYYYVRIV YRRHHPRYQN PQIAALLQLQ P