ID   E3145_ADE03             Reviewed;         136 AA.
AC   P11315;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Early E3 15.3 kDa protein;
OS   Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=45659;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3582978; DOI=10.1016/0378-1119(86)90322-7;
RA   Signaes C., Akusjaervi G., Pettersson U.;
RT   "Region E3 of human adenoviruses; differences between the oncogenic
RT   adenovirus-3 and the non-oncogenic adenovirus-2.";
RL   Gene 50:173-184(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-136.
RX   PubMed=2982041; DOI=10.1128/jvi.53.2.672-678.1985;
RA   Signaes C., Akusjaervi G., Pettersson U.;
RT   "Adenovirus 3 fiber polypeptide gene: implications for the structure of the
RT   fiber protein.";
RL   J. Virol. 53:672-678(1985).
RN   [3]
RP   IDENTIFICATION OF PROTEIN.
RX   PubMed=2304142; DOI=10.1128/jvi.64.3.1250-1255.1990;
RA   Horton T.H., Tollefson A.E., Wold W.S.M., Gooding L.R.;
RT   "A protein serologically and functionally related to the group C E3 14,700-
RT   kilodalton protein is found in multiple adenovirus serotypes.";
RL   J. Virol. 64:1250-1255(1990).
CC   -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR   EMBL; M15952; AAA42489.1; -; Genomic_DNA.
DR   EMBL; X01998; CAA26028.1; -; Genomic_DNA.
DR   PIR; A27623; ERAD29.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004985; Adeno_E3-15.
DR   Pfam; PF03307; Adeno_E3_15_3; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..136
FT                   /note="Early E3 15.3 kDa protein"
FT                   /id="PRO_0000221746"
SQ   SEQUENCE   136 AA;  15266 MW;  DFD57C08897A82D8 CRC64;
     MTDPIATSST AAKELLDMDG RASEQRLIQL RIRQQQERAV KELRDAIGIH QCKKGIFCLV
     KQSKISYEIT ATDHRLSYEL GPQRQKFTCM VGINPIVITQ QSGDTKGCIQ CSCDSTECIY
     TLLKTLCGLR DLLPMN