ADM5_HUMAN
ID ADM5_HUMAN Reviewed; 153 AA.
AC C9JUS6;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Putative adrenomedullin-5-like protein;
DE Flags: Precursor;
GN Name=ADM5; Synonyms=C19orf76;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=18434369; DOI=10.1677/joe-07-0541;
RA Takei Y., Hashimoto H., Inoue K., Osaki T., Yoshizawa-Kumagaye K.,
RA Tsunemi M., Watanabe T.X., Ogoshi M., Minamino N., Ueta Y.;
RT "Central and peripheral cardiovascular actions of adrenomedullin 5, a novel
RT member of the calcitonin gene-related peptide family, in mammals.";
RL J. Endocrinol. 197:391-400(2008).
CC -!- FUNCTION: Probable non-functional remnant of adrenomedullin-5.
CC {ECO:0000269|PubMed:18434369}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the adrenomedullin family. {ECO:0000305}.
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DR EMBL; AC011495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471177; EAW52522.1; -; Genomic_DNA.
DR EMBL; BC032764; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS46146.1; -.
DR RefSeq; NP_001094810.1; NM_001101340.1.
DR AlphaFoldDB; C9JUS6; -.
DR BioGRID; 128275; 24.
DR STRING; 9606.ENSP00000393631; -.
DR BioMuta; ADM5; -.
DR PaxDb; C9JUS6; -.
DR PeptideAtlas; C9JUS6; -.
DR PRIDE; C9JUS6; -.
DR Antibodypedia; 66610; 3 antibodies from 3 providers.
DR DNASU; 199800; -.
DR Ensembl; ENST00000420022.4; ENSP00000393631.2; ENSG00000224420.4.
DR GeneID; 199800; -.
DR KEGG; hsa:199800; -.
DR MANE-Select; ENST00000420022.4; ENSP00000393631.2; NM_001101340.2; NP_001094810.1.
DR UCSC; uc002pph.3; human.
DR CTD; 199800; -.
DR DisGeNET; 199800; -.
DR GeneCards; ADM5; -.
DR HGNC; HGNC:27293; ADM5.
DR HPA; ENSG00000224420; Low tissue specificity.
DR neXtProt; NX_C9JUS6; -.
DR OpenTargets; ENSG00000224420; -.
DR PharmGKB; PA165393101; -.
DR VEuPathDB; HostDB:ENSG00000224420; -.
DR eggNOG; ENOG502RJSC; Eukaryota.
DR GeneTree; ENSGT00730000112484; -.
DR HOGENOM; CLU_147097_0_0_1; -.
DR InParanoid; C9JUS6; -.
DR OMA; PLQLWAP; -.
DR OrthoDB; 1305602at2759; -.
DR PhylomeDB; C9JUS6; -.
DR PathwayCommons; C9JUS6; -.
DR BioGRID-ORCS; 199800; 21 hits in 1079 CRISPR screens.
DR GenomeRNAi; 199800; -.
DR Pharos; C9JUS6; Tdark.
DR PRO; PR:C9JUS6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; C9JUS6; protein.
DR Bgee; ENSG00000224420; Expressed in lower esophagus mucosa and 103 other tissues.
DR Genevisible; C9JUS6; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031700; F:adrenomedullin receptor binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010460; P:positive regulation of heart rate; IBA:GO_Central.
DR GO; GO:0003073; P:regulation of systemic arterial blood pressure; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..153
FT /note="Putative adrenomedullin-5-like protein"
FT /id="PRO_0000392551"
FT DISULFID 39..44
FT /evidence="ECO:0000250"
SQ SEQUENCE 153 AA; 16532 MW; 2AC1CFBEB867B30D CRC64;
MTIHILILLL LLAFSAQGDL DTAARRGQHQ VPQHRGHVCY LGVCRTHRLA EIIYWIRCLH
QGALGEGQPR APGPLQLWAP PVARGGSPAR FPGFRPAARG LAQCPARWVT SGTARPLLGF
SLPICMLELL LHISSPLTPA PETVFPSPSP GCD
