ID   E3145_ADE05             Reviewed;         128 AA.
AC   P04493;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Early E3 14.5 kDa protein;
OS   Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=28285;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2981456; DOI=10.1016/0042-6822(85)90443-x;
RA   Cladaras C., Wold W.S.M.;
RT   "DNA sequence of the early E3 transcription unit of adenovirus 5.";
RL   Virology 140:28-43(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1727603; DOI=10.1016/0042-6822(92)90082-z;
RA   Chroboczek J., Bieber F., Jacrot B.;
RT   "The sequence of the genome of adenovirus type 5 and its comparison with
RT   the genome of adenovirus type 2.";
RL   Virology 186:280-285(1992).
RN   [3]
RP   IDENTIFICATION OF PROTEIN.
RX   PubMed=2304142; DOI=10.1128/jvi.64.3.1250-1255.1990;
RA   Horton T.H., Tollefson A.E., Wold W.S.M., Gooding L.R.;
RT   "A protein serologically and functionally related to the group C E3 14,700-
RT   kilodalton protein is found in multiple adenovirus serotypes.";
RL   J. Virol. 64:1250-1255(1990).
CC   -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR   EMBL; M73260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X03002; CAA26787.1; -; Genomic_DNA.
DR   PIR; A03819; ERAD45.
DR   RefSeq; AP_000224.1; AC_000008.1.
DR   PRIDE; P04493; -.
DR   Proteomes; UP000004992; Genome.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004985; Adeno_E3-15.
DR   Pfam; PF03307; Adeno_E3_15_3; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..128
FT                   /note="Early E3 14.5 kDa protein"
FT                   /id="PRO_0000221747"
SQ   SEQUENCE   128 AA;  14598 MW;  87A725A5D229141B CRC64;
     MTDTLDLEMD GIITEQRLLE RRRAAAEQQR MNQELQDMVN LHQCKRGIFC LVKQAKVTYD
     SNTTGHRLSY KLPTKRQKLV VMVGEKPITI TQHSVETEGC IHSPCQGPED LCTLIKTLCG
     LKDLIPFN