E3145_ADE06
ID E3145_ADE06 Reviewed; 128 AA.
AC P68977; P03249;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Early E3B 14 kDa protein;
OS Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus.
OX NCBI_TaxID=10534;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D.,
RA Bauer U., Flunker G., Seidel W.;
RT "Sequence analysis of group C human adenoviruses type 1 and 6 for five
RT genes of region E3.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR EMBL; Y16037; CAA75994.1; -; Genomic_DNA.
DR GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR004985; Adeno_E3-15.
DR Pfam; PF03307; Adeno_E3_15_3; 1.
PE 3: Inferred from homology;
KW Early protein; Host-virus interaction;
KW Inhibition of host caspases by virus;
KW Modulation of host cell apoptosis by virus.
FT CHAIN 1..128
FT /note="Early E3B 14 kDa protein"
FT /id="PRO_0000221748"
SQ SEQUENCE 128 AA; 14738 MW; 09882D90B253F146 CRC64;
MTESLDLELD GINTEQRLLE RRKAASERER LKQEVEDMVN LHQCKRGIFC VVKQAKLTYE
KTTTGNRLSY KLPTQRQKLV LMVGEKPITV TQHSAETEGC LHFPYQGPED LCTLIKTMCG
IRDLIPFN