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E3145_ADE06
ID   E3145_ADE06             Reviewed;         128 AA.
AC   P68977; P03249;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Early E3B 14 kDa protein;
OS   Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=10534;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D.,
RA   Bauer U., Flunker G., Seidel W.;
RT   "Sequence analysis of group C human adenoviruses type 1 and 6 for five
RT   genes of region E3.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR   EMBL; Y16037; CAA75994.1; -; Genomic_DNA.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004985; Adeno_E3-15.
DR   Pfam; PF03307; Adeno_E3_15_3; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..128
FT                   /note="Early E3B 14 kDa protein"
FT                   /id="PRO_0000221748"
SQ   SEQUENCE   128 AA;  14738 MW;  09882D90B253F146 CRC64;
     MTESLDLELD GINTEQRLLE RRKAASERER LKQEVEDMVN LHQCKRGIFC VVKQAKLTYE
     KTTTGNRLSY KLPTQRQKLV LMVGEKPITV TQHSAETEGC LHFPYQGPED LCTLIKTMCG
     IRDLIPFN
 
 
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