ID   E3145_ADE07             Reviewed;         135 AA.
AC   P15135;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Early E3 15.3 kDa protein;
OS   Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=10519;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gomen;
RX   PubMed=2849239;
RA   Hong J.S., Mullis K.G., Engler J.A.;
RT   "Characterization of the early region 3 and fiber genes of Ad7.";
RL   Virology 167:545-553(1988).
RN   [2]
RP   IDENTIFICATION OF PROTEIN.
RX   PubMed=2304142; DOI=10.1128/jvi.64.3.1250-1255.1990;
RA   Horton T.H., Tollefson A.E., Wold W.S.M., Gooding L.R.;
RT   "A protein serologically and functionally related to the group C E3 14,700-
RT   kilodalton protein is found in multiple adenovirus serotypes.";
RL   J. Virol. 64:1250-1255(1990).
CC   -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR   EMBL; M23696; AAA53253.1; -; Genomic_DNA.
DR   PIR; E31830; ERAD74.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004985; Adeno_E3-15.
DR   Pfam; PF03307; Adeno_E3_15_3; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..135
FT                   /note="Early E3 15.3 kDa protein"
FT                   /id="PRO_0000221749"
SQ   SEQUENCE   135 AA;  15363 MW;  4D2E51C8AA6220BC CRC64;
     MTEILTTSNS AEDLLDMDGR VSEQRLAQLR IRQQQERVTK ELRDVIQIHQ CKKGIFCLVK
     QAKISYEITA TDHRLSYELG PQRQKFTCMV GINPIVITQQ SGDTKGCIHC SCDSIECTYT
     LLKTLCGLRD LLPMN