ID   E3145_ADEB3             Reviewed;         121 AA.
AC   Q03552;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Early E3 14.5 kDa protein;
GN   Name=E3;
OS   Bovine adenovirus B serotype 3 (BAdV-3) (Mastadenovirus bos3).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Bovine mastadenovirus B.
OX   NCBI_TaxID=10510;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1469367; DOI=10.1099/0022-1317-73-12-3295;
RA   Mittal S.K., Prevec L., Babiuk L.A., Graham F.L.;
RT   "Sequence analysis of bovine adenovirus type 3 early region 3 and fibre
RT   protein genes.";
RL   J. Gen. Virol. 73:3295-3300(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8277294; DOI=10.1099/0022-1317-74-12-2825;
RA   Mittal S.K., Prevec L., Babiuk L.A., Graham F.L.;
RT   "Sequence analysis of bovine adenovirus type 3 early region 3 and fibre
RT   protein genes.";
RL   J. Gen. Virol. 74:2825-2825(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WBR-1;
RX   PubMed=9445040; DOI=10.1128/jvi.72.2.1394-1402.1998;
RA   Reddy P.S., Idamakanti N., Zakhartchouk A.N., Baxi M.K., Lee J.B., Pyne C.,
RA   Babiuk L.A., Tikoo S.K.;
RT   "Nucleotide sequence, genome organization, and transcription map of bovine
RT   adenovirus type 3.";
RL   J. Virol. 72:1394-1402(1998).
CC   -!- FUNCTION: Protects virus-infected cells from TNF-induced cytolysis.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_15 family. {ECO:0000305}.
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DR   EMBL; D16839; BAA04114.1; -; Genomic_DNA.
DR   EMBL; AF030154; AAD09735.1; -; Genomic_DNA.
DR   RefSeq; NP_046330.1; NC_001876.1.
DR   GeneID; 2652955; -.
DR   KEGG; vg:2652955; -.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:InterPro.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004985; Adeno_E3-15.
DR   Pfam; PF03307; Adeno_E3_15_3; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..121
FT                   /note="Early E3 14.5 kDa protein"
FT                   /id="PRO_0000221750"
SQ   SEQUENCE   121 AA;  13276 MW;  F1E8B82E9337B470 CRC64;
     MEPDGVHAEQ QFILNQISCA NTALQRQREE LASLVMLHAC KRGLFCPVKT YKLSLNASAS
     EHSLHFEKSP SRFTLVNTHA GASVRVALHH QGASGSIRCS CSHAECLPVL LKTLCAFNFL
     D