ID   E3B14_ADE03             Reviewed;         134 AA.
AC   P11316;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   12-AUG-2020, entry version 66.
DE   RecName: Full=Early E3B 14.5 kDa protein;
DE   AltName: Full=Early E3B 15.2 kDa glycoprotein;
DE   Flags: Precursor;
OS   Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=45659;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3582978; DOI=10.1016/0378-1119(86)90322-7;
RA   Signaes C., Akusjaervi G., Pettersson U.;
RT   "Region E3 of human adenoviruses; differences between the oncogenic
RT   adenovirus-3 and the non-oncogenic adenovirus-2.";
RL   Gene 50:173-184(1986).
CC   -!- FUNCTION: Down-regulates the EGF receptor and prevents cytolysis by
CC       TNF.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated on serine; O-glycosylated, but not N-glycosylated.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_14 family. {ECO:0000305}.
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DR   EMBL; M15952; AAA42488.1; -; Genomic_DNA.
DR   PIR; I29500; ERAD28.
DR   PRIDE; P11316; -.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR008131; Adeno_E3_14_5.
DR   Pfam; PF04834; Adeno_E3_14_5; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host membrane; Membrane; Phosphoprotein;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..134
FT                   /note="Early E3B 14.5 kDa protein"
FT                   /id="PRO_0000036478"
FT   TRANSMEM        54..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   134 AA;  15240 MW;  CD33D9E92C697B49 CRC64;
     MQAMLPVILI LLLPCIPLAS TATRATPEQL RKCKFQQPWS FLDCYHEKSD FPTYWIVIVG
     IINILSCTFF SITIYPTFNF GWNSPNALGY PQEPDEHIPL QHIQQPLALV QYENEPQPSL
     PPAISYFNLT GGDD