ID   E3B14_ADE06             Reviewed;         130 AA.
AC   O55655;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   12-AUG-2020, entry version 54.
DE   RecName: Full=Early E3B 14.5 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=10534;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D.,
RA   Bauer U., Flunker G., Seidel W.;
RT   "Sequence analysis of group C human adenoviruses type 1 and 6 for five
RT   genes of region E3.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Down-regulates the EGF receptor and prevents cytolysis by
CC       TNF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated on serine; O-glycosylated, but not N-glycosylated.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_14 family. {ECO:0000305}.
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DR   EMBL; Y16037; CAA75993.1; -; Genomic_DNA.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR008131; Adeno_E3_14_5.
DR   Pfam; PF04834; Adeno_E3_14_5; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host membrane; Membrane; Phosphoprotein;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..130
FT                   /note="Early E3B 14.5 kDa protein"
FT                   /id="PRO_0000036477"
FT   TRANSMEM        53..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  14558 MW;  5A4DD1F693CB1921 CRC64;
     MKRIVTFVLL IFCALPVLCS QTSAPPKRHI SCRFTQIWNI PSCYNKQSDL SEAWLYAIIS
     VMVFCSTIFA LAIYPYLDIG WNAIDAMNHP TFPAPNVIPL QQVIAPINQP RPPSPTPTEI
     SYFNLTGGDD