ID   E3B14_ADE07             Reviewed;         134 AA.
AC   P15136;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   02-DEC-2020, entry version 71.
DE   RecName: Full=Early E3B 14.9 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=10519;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gomen;
RX   PubMed=2849239;
RA   Hong J.S., Mullis K.G., Engler J.A.;
RT   "Characterization of the early region 3 and fiber genes of Ad7.";
RL   Virology 167:545-553(1988).
CC   -!- FUNCTION: Down-regulates the EGF receptor and prevents cytolysis by
CC       TNF.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated on serine; O-glycosylated, but not N-glycosylated.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_14 family. {ECO:0000305}.
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DR   EMBL; M23696; AAA53252.1; -; Genomic_DNA.
DR   PIR; D31830; ERAD78.
DR   RefSeq; AP_000561.1; AC_000018.1.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR008131; Adeno_E3_14_5.
DR   Pfam; PF04834; Adeno_E3_14_5; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host membrane; Membrane; Phosphoprotein;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..134
FT                   /note="Early E3B 14.9 kDa protein"
FT                   /id="PRO_0000036480"
FT   TRANSMEM        54..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   134 AA;  15215 MW;  CC67D9F82C65CD95 CRC64;
     MQAMLPVILI LLLPCIALAS TATRATPEQL RKCKFQQPWS FLDCYHEKSD FPTYWIVIVG
     IINILSCTFF SITIYPTFNF GWNSPNALGY PQEPDEHIPL QHIQQPLALV EYENEPQPSL
     PPAISYFNLT GGDD