ID   E3B14_ADE12             Reviewed;         110 AA.
AC   P36707;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   02-JUN-2021, entry version 70.
DE   RecName: Full=Early E3B 12.7 kDa protein;
DE   Flags: Precursor;
OS   Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus A.
OX   NCBI_TaxID=28282;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8254750; DOI=10.1128/jvi.68.1.379-389.1994;
RA   Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W.;
RT   "Nucleotide sequence of human adenovirus type 12 DNA: comparative
RT   functional analysis.";
RL   J. Virol. 68:379-389(1994).
CC   -!- FUNCTION: Down-regulates the EGF receptor and prevents cytolysis by
CC       TNF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated on serine; O-glycosylated, but not N-glycosylated.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae E3_14 family. {ECO:0000305}.
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DR   EMBL; X73487; CAA51899.1; -; Genomic_DNA.
DR   PIR; S33950; S33950.
DR   RefSeq; NP_040931.1; NC_001460.1.
DR   DNASU; 1460862; -.
DR   GeneID; 1460862; -.
DR   Proteomes; UP000004993; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR008131; Adeno_E3_14_5.
DR   Pfam; PF04834; Adeno_E3_14_5; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host membrane; Membrane; Phosphoprotein;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..110
FT                   /note="Early E3B 12.7 kDa protein"
FT                   /id="PRO_0000036481"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  12765 MW;  2D71804378AF967C CRC64;
     MKTALVLFFM LIPVWASSCQ LHKPWNFLDC YTKETNYIGW VYGIMSGLVF VSSVVSLQLY
     ARLNFSWNKY TDDLPEYPNP QDDLPLNIVF PEPPRPPSVV SYFKFTGEDD