E400N_HUMAN
ID E400N_HUMAN Reviewed; 488 AA.
AC Q6ZTU2; A6NLB7; A8K0Z5; B3KQY2; Q6NXP1; Q8N253; Q8N7S7; Q9UFJ3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Putative EP400-like protein {ECO:0000305};
DE AltName: Full=EP400 pseudogene 1 {ECO:0000312|HGNC:HGNC:26602};
GN Name=EP400P1 {ECO:0000312|HGNC:HGNC:26602};
GN Synonyms=EP400NL {ECO:0000312|HGNC:HGNC:26602};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Brain, Glial tumor, Testis, Thymus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-488 (ISOFORM 5).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6ZTU2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZTU2-2; Sequence=VSP_030443, VSP_030446;
CC Name=3;
CC IsoId=Q6ZTU2-4; Sequence=VSP_030442, VSP_030445, VSP_030446;
CC Name=4;
CC IsoId=Q6ZTU2-5; Sequence=VSP_030442, VSP_030447;
CC Name=5;
CC IsoId=Q6ZTU2-6; Sequence=VSP_030447;
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB56026.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK090610; BAG52194.1; -; mRNA.
DR EMBL; AK091234; BAC03617.1; -; mRNA.
DR EMBL; AK097720; BAC05150.1; -; mRNA.
DR EMBL; AK126212; BAC86487.1; -; mRNA.
DR EMBL; AK289710; BAF82399.1; -; mRNA.
DR EMBL; AC138466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL117637; CAB56026.2; ALT_INIT; mRNA.
DR PIR; T17336; T17336.
DR AlphaFoldDB; Q6ZTU2; -.
DR IntAct; Q6ZTU2; 5.
DR GlyGen; Q6ZTU2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZTU2; -.
DR PhosphoSitePlus; Q6ZTU2; -.
DR BioMuta; HGNC:26602; -.
DR DMDM; 166922146; -.
DR EPD; Q6ZTU2; -.
DR jPOST; Q6ZTU2; -.
DR MassIVE; Q6ZTU2; -.
DR MaxQB; Q6ZTU2; -.
DR PaxDb; Q6ZTU2; -.
DR PeptideAtlas; Q6ZTU2; -.
DR PRIDE; Q6ZTU2; -.
DR ProteomicsDB; 68291; -. [Q6ZTU2-1]
DR ProteomicsDB; 68292; -. [Q6ZTU2-2]
DR ProteomicsDB; 68293; -. [Q6ZTU2-4]
DR ProteomicsDB; 68294; -. [Q6ZTU2-5]
DR ProteomicsDB; 68295; -. [Q6ZTU2-6]
DR UCSC; uc001ujt.3; human. [Q6ZTU2-1]
DR GeneCards; EP400P1; -.
DR HGNC; HGNC:26602; EP400P1.
DR neXtProt; NX_Q6ZTU2; -.
DR eggNOG; KOG0391; Eukaryota.
DR InParanoid; Q6ZTU2; -.
DR PhylomeDB; Q6ZTU2; -.
DR TreeFam; TF342061; -.
DR PathwayCommons; Q6ZTU2; -.
DR SignaLink; Q6ZTU2; -.
DR ChiTaRS; EP400NL; human.
DR Pharos; Q6ZTU2; Tdark.
DR PRO; PR:Q6ZTU2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6ZTU2; protein.
DR Genevisible; Q6ZTU2; HS.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR InterPro; IPR031575; EP400_N.
DR Pfam; PF15790; EP400_N; 1.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..488
FT /note="Putative EP400-like protein"
FT /id="PRO_0000314949"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 51..182
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030442"
FT VAR_SEQ 51..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030443"
FT VAR_SEQ 254..274
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030445"
FT VAR_SEQ 466..488
FT /note="QIHMGTPVPGDVNSIKMEASKRQ -> PLAPTTVLSVSADWNALLQRPNKYI
FT WGLQYLEM (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030446"
FT VAR_SEQ 466..488
FT /note="QIHMGTPVPGDVNSIKMEASKRQ -> VLSDGSTVQLPRLSSLGFEDSMC
FT (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_030447"
FT CONFLICT 179
FT /note="F -> L (in Ref. 1; BAC86487)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="S -> G (in Ref. 1; BAC03617)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="P -> S (in Ref. 1; BAC86487)"
FT /evidence="ECO:0000305"
FT CONFLICT 452
FT /note="R -> W (in Ref. 1; BAC03617)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 488 AA; 51753 MW; 97A94BCED9AF8B54 CRC64;
MQHVSSSQSS QRHVQWPGAC PGAGEEQPAC SQPSLPLTLP SPSHQLQQLM VRGGPAGGQN
MNVDLQGVGP GLQGSPQVTL APLPLPSPTS PGFQFSAQPR RFEHGSPSYI QVTSPLSQQV
QTQSPTQPSP GPGQALQNVR AGAPGPGLGL CSSSPTGDFV DASVLVRQIS LSPSSGGHFV
FQDGSGLTQI AQGAQVQLQH PGTPITVRER RPSQPHTQSG GTIHHLGPQS PAAAGGAGLQ
PLASPSHITT ANLPPQISSI IQGQLVQQQQ VLQGPPLPRP LGFERTPGVL LPGAGGAAGF
GMTSPPPPTS PSRTAVPPGL SSLPLTSVGN TGMKKVPKKL EEIPPASPEM AQMRKQCLDY
HHQEMQALKE VFKEYLIELF FLQHFQGNMM DFLAFKERLY GPLQAYLRQN DLDIEEEEEE
HFEVINDEVK VVARKHGQPG TPVAIATQLP PRTSAAFPAQ QQPLQQIHMG TPVPGDVNSI
KMEASKRQ
