ID   E41LA_DANRE             Reviewed;         619 AA.
AC   O57457;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Band 4.1-like protein 4;
DE   AltName: Full=Erythrocyte membrane protein band 4.1-like 4A {ECO:0000250|UniProtKB:Q9HCS5};
DE   AltName: Full=Protein Nbl4;
GN   Name=epb41l4a {ECO:0000250|UniProtKB:Q9HCS5}; Synonyms=epb4.1l4, nbl4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9551184; DOI=10.1139/o97-078;
RA   Kelly G.M., Reversade B.;
RT   "Characterization of a cDNA encoding a novel band 4.1-like protein in
RT   zebrafish.";
RL   Biochem. Cell Biol. 75:623-632(1997).
CC   -!- FUNCTION: Not known, binds calmodulin.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In adults, it is found in the ovary, eye, heart and
CC       brain, but not in gut or skeletal muscle.
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DR   EMBL; AF025306; AAB97965.1; -; mRNA.
DR   AlphaFoldDB; O57457; -.
DR   SMR; O57457; -.
DR   STRING; 7955.ENSDARP00000058626; -.
DR   PaxDb; O57457; -.
DR   PRIDE; O57457; -.
DR   ZFIN; ZDB-GENE-990415-20; epb41l4a.
DR   eggNOG; KOG3530; Eukaryota.
DR   InParanoid; O57457; -.
DR   PhylomeDB; O57457; -.
DR   PRO; PR:O57457; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR030696; Band4.1-like4A.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014847; FERM-adjacent.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280:SF4; PTHR23280:SF4; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..619
FT                   /note="Band 4.1-like protein 4"
FT                   /id="PRO_0000219403"
FT   DOMAIN          11..299
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          323..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..463
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..526
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  70709 MW;  0DFD7324DE513663 CRC64;
     MSCFCSVQEE FYCEVLLLDE SKLILTTQQQ GIKKSTRGSV VLDYVFSHVN LAETEYFGVR
     YCDRSHQTFW LDPSKTLAEH KDLIATGPPY TLYFGVKFYA EDPGKLKEEI TRYQFFLQVK
     QDVLQGRLPC AFNISAQLAA LAIQSELGDY DPYKHTAGYV SEYRFVPDQK EDLEDSIEQI
     HKTLLGQVPA EAENNYLAIA KTLEMYGVDL HPVFGEKQAE YFLGLTPVGV VVYKNKTQVG
     KYFWPRITKV YFKETQFELR VLGRDCNETS FFFDAASKTA CKNLWKCCVE HHTFFRMPEN
     ESNSLTRKLS KFSSLGSKHR YSGKTAMQIG RESTETLPRA DLQVIRTRSK TYPKRSTQPA
     GRNNGGQAVT KMENTSEGQP KTSALTPVKS PRVKAESASV QQEKPSAPWE EDAPQSGLYN
     SASERNKSPK FPKAHRRSPS GGSENEPRHR RGQTADDAQA NKQHRRRSRS RGNTSSGSES
     ENSNREHRKK RNRSRQSNEM VDSAPQWEVV LRRQKEKTPN DPNQRRSRHR SRSRSPDVQA
     KEQLWKHIQK ELVDPSGLSE EQLKEIPYKK VETQGDPIKI RHSHSPRSFG STGAPTARTE
     RGLCCPKSTL ALIWFLLWL