E41LA_MOUSE
ID E41LA_MOUSE Reviewed; 686 AA.
AC P52963; Q91VX6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Band 4.1-like protein 4A;
DE AltName: Full=Erythrocyte membrane protein band 4.1-like 4A {ECO:0000312|MGI:MGI:103007};
DE AltName: Full=Protein NBL4;
GN Name=Epb41l4a {ECO:0000312|MGI:MGI:103007};
GN Synonyms=Epb4.1l4, Epb4.1l4a {ECO:0000312|MGI:MGI:103007}, Epb41l4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-556.
RX PubMed=7983158; DOI=10.1242/jcs.107.7.1921;
RA Takeuchi K., Kawashima A., Nagafuchi A., Tsukita S.;
RT "Structural diversity of band 4.1 superfamily members.";
RL J. Cell Sci. 107:1921-1928(1994).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Brain, heart, lung, liver and spleen. Not detected
CC in thymus and kidney.
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DR EMBL; BC007166; AAH07166.1; -; mRNA.
DR EMBL; BC013557; AAH13557.1; -; mRNA.
DR EMBL; D28818; BAA05978.1; -; mRNA.
DR CCDS; CCDS29124.1; -.
DR PIR; I55505; JU0188.
DR RefSeq; NP_038540.2; NM_013512.2.
DR AlphaFoldDB; P52963; -.
DR SMR; P52963; -.
DR BioGRID; 199462; 10.
DR STRING; 10090.ENSMUSP00000025234; -.
DR iPTMnet; P52963; -.
DR PhosphoSitePlus; P52963; -.
DR MaxQB; P52963; -.
DR PaxDb; P52963; -.
DR PeptideAtlas; P52963; -.
DR PRIDE; P52963; -.
DR ProteomicsDB; 277746; -.
DR Antibodypedia; 25339; 115 antibodies from 21 providers.
DR DNASU; 13824; -.
DR Ensembl; ENSMUST00000025234; ENSMUSP00000025234; ENSMUSG00000024376.
DR GeneID; 13824; -.
DR KEGG; mmu:13824; -.
DR UCSC; uc008ejx.1; mouse.
DR CTD; 64097; -.
DR MGI; MGI:103007; Epb41l4a.
DR VEuPathDB; HostDB:ENSMUSG00000024376; -.
DR eggNOG; KOG3530; Eukaryota.
DR GeneTree; ENSGT00940000159623; -.
DR HOGENOM; CLU_003623_7_0_1; -.
DR InParanoid; P52963; -.
DR OMA; TYPKRVA; -.
DR OrthoDB; 241659at2759; -.
DR PhylomeDB; P52963; -.
DR TreeFam; TF319780; -.
DR BioGRID-ORCS; 13824; 0 hits in 40 CRISPR screens.
DR ChiTaRS; Epb41l4a; mouse.
DR PRO; PR:P52963; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; P52963; protein.
DR Bgee; ENSMUSG00000024376; Expressed in epithelium of lens and 212 other tissues.
DR Genevisible; P52963; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR030696; Band4.1-like4A.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FERM-adjacent.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280:SF4; PTHR23280:SF4; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..686
FT /note="Band 4.1-like protein 4A"
FT /id="PRO_0000219402"
FT DOMAIN 11..299
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 332..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT MOD_RES 389
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT CONFLICT 322..323
FT /note="Missing (in Ref. 2; BAA05978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 78533 MW; BB915F6434AB5905 CRC64;
MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFRHIN LVEIDYFGLR
YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA EDPCKLKEEI TRYQFFLQVK
QDALQGRLPC PVNIAAQMGA YAIQAELGDH DPYKHTAGYV SEYRFVPDQK EELEEAIERI
HKTLMGQAPS EAELNYLRTA KSLEMYGVDL HPVYGENKSE YFLGLTPSGV VVYKNKKQVG
KYFWPRITKV HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPDT
ESNSLSRKLS KFGSISYKHR YSGRTALQMS RDLSIQLPRP NQNVVRSRSK TYPKRVAQTQ
PTGSNNINRI TANTENGENE GTTKIIAPSP VKSFKKAKNE NSPDPQRSKS HAPWEENGPQ
SGLYNSSSDR TKSPKFPCAR QRNLSCGSDN DSSQLMRRRK AHNSGEDSDL KQRRRSRSRC
NTSSGSESEN SNREHRKKRN RTRQENDMVD SGPQWEAVLR RQKEKNQADP NNRRSRHRSR
SRSPDIQAKE ELWKHIQKEL VDPSGLSEEQ LKEIPYTKVE TQGDPVRIRH SHSPRSYRQY
RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGGS TVHQRRNGSK DSLIEEKSQL
STINPAGKPT AKTIKTIQAA RLKAET