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E41LA_MOUSE
ID   E41LA_MOUSE             Reviewed;         686 AA.
AC   P52963; Q91VX6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Band 4.1-like protein 4A;
DE   AltName: Full=Erythrocyte membrane protein band 4.1-like 4A {ECO:0000312|MGI:MGI:103007};
DE   AltName: Full=Protein NBL4;
GN   Name=Epb41l4a {ECO:0000312|MGI:MGI:103007};
GN   Synonyms=Epb4.1l4, Epb4.1l4a {ECO:0000312|MGI:MGI:103007}, Epb41l4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-556.
RX   PubMed=7983158; DOI=10.1242/jcs.107.7.1921;
RA   Takeuchi K., Kawashima A., Nagafuchi A., Tsukita S.;
RT   "Structural diversity of band 4.1 superfamily members.";
RL   J. Cell Sci. 107:1921-1928(1994).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain, heart, lung, liver and spleen. Not detected
CC       in thymus and kidney.
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DR   EMBL; BC007166; AAH07166.1; -; mRNA.
DR   EMBL; BC013557; AAH13557.1; -; mRNA.
DR   EMBL; D28818; BAA05978.1; -; mRNA.
DR   CCDS; CCDS29124.1; -.
DR   PIR; I55505; JU0188.
DR   RefSeq; NP_038540.2; NM_013512.2.
DR   AlphaFoldDB; P52963; -.
DR   SMR; P52963; -.
DR   BioGRID; 199462; 10.
DR   STRING; 10090.ENSMUSP00000025234; -.
DR   iPTMnet; P52963; -.
DR   PhosphoSitePlus; P52963; -.
DR   MaxQB; P52963; -.
DR   PaxDb; P52963; -.
DR   PeptideAtlas; P52963; -.
DR   PRIDE; P52963; -.
DR   ProteomicsDB; 277746; -.
DR   Antibodypedia; 25339; 115 antibodies from 21 providers.
DR   DNASU; 13824; -.
DR   Ensembl; ENSMUST00000025234; ENSMUSP00000025234; ENSMUSG00000024376.
DR   GeneID; 13824; -.
DR   KEGG; mmu:13824; -.
DR   UCSC; uc008ejx.1; mouse.
DR   CTD; 64097; -.
DR   MGI; MGI:103007; Epb41l4a.
DR   VEuPathDB; HostDB:ENSMUSG00000024376; -.
DR   eggNOG; KOG3530; Eukaryota.
DR   GeneTree; ENSGT00940000159623; -.
DR   HOGENOM; CLU_003623_7_0_1; -.
DR   InParanoid; P52963; -.
DR   OMA; TYPKRVA; -.
DR   OrthoDB; 241659at2759; -.
DR   PhylomeDB; P52963; -.
DR   TreeFam; TF319780; -.
DR   BioGRID-ORCS; 13824; 0 hits in 40 CRISPR screens.
DR   ChiTaRS; Epb41l4a; mouse.
DR   PRO; PR:P52963; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; P52963; protein.
DR   Bgee; ENSMUSG00000024376; Expressed in epithelium of lens and 212 other tissues.
DR   Genevisible; P52963; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR030696; Band4.1-like4A.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FERM-adjacent.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280:SF4; PTHR23280:SF4; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..686
FT                   /note="Band 4.1-like protein 4A"
FT                   /id="PRO_0000219402"
FT   DOMAIN          11..299
FT                   /note="FERM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT   REGION          332..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..411
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..476
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..534
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..647
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..669
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT   MOD_RES         389
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT   MOD_RES         393
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT   MOD_RES         402
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCS5"
FT   CONFLICT        322..323
FT                   /note="Missing (in Ref. 2; BAA05978)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   686 AA;  78533 MW;  BB915F6434AB5905 CRC64;
     MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFRHIN LVEIDYFGLR
     YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA EDPCKLKEEI TRYQFFLQVK
     QDALQGRLPC PVNIAAQMGA YAIQAELGDH DPYKHTAGYV SEYRFVPDQK EELEEAIERI
     HKTLMGQAPS EAELNYLRTA KSLEMYGVDL HPVYGENKSE YFLGLTPSGV VVYKNKKQVG
     KYFWPRITKV HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPDT
     ESNSLSRKLS KFGSISYKHR YSGRTALQMS RDLSIQLPRP NQNVVRSRSK TYPKRVAQTQ
     PTGSNNINRI TANTENGENE GTTKIIAPSP VKSFKKAKNE NSPDPQRSKS HAPWEENGPQ
     SGLYNSSSDR TKSPKFPCAR QRNLSCGSDN DSSQLMRRRK AHNSGEDSDL KQRRRSRSRC
     NTSSGSESEN SNREHRKKRN RTRQENDMVD SGPQWEAVLR RQKEKNQADP NNRRSRHRSR
     SRSPDIQAKE ELWKHIQKEL VDPSGLSEEQ LKEIPYTKVE TQGDPVRIRH SHSPRSYRQY
     RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGGS TVHQRRNGSK DSLIEEKSQL
     STINPAGKPT AKTIKTIQAA RLKAET
 
 
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