ADML_BOVIN
ID ADML_BOVIN Reviewed; 188 AA.
AC O62827; Q08DC5; Q95KP0;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Pro-adrenomedullin;
DE Contains:
DE RecName: Full=Adrenomedullin;
DE Short=AM;
DE Contains:
DE RecName: Full=Adrenomedullin-11-26;
DE Short=AM 11-26;
DE Contains:
DE RecName: Full=Proadrenomedullin N-20 terminal peptide;
DE AltName: Full=ProAM N-terminal 20 peptide;
DE Short=PAMP;
DE Short=ProAM-N20;
DE Flags: Precursor;
GN Name=ADM;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Aorta;
RX PubMed=9585168; DOI=10.1016/s0024-3205(98)00079-4;
RA Barker S., Wood E., Clark A.J.L., Corder R.;
RT "Cloning of bovine preproadrenomedullin and inhibition of its basal
RT expression in vascular endothelial cells by staurosporine.";
RL Life Sci. 62:1407-1415(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION OF AM 11-26.
RX PubMed=11754956; DOI=10.1016/s0196-9781(01)00529-0;
RA Kitamura K., Matsui E., Kato J., Katoh F., Kita T., Tsuji T., Kangawa K.,
RA Eto T.;
RT "Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated
RT from bovine adrenal medulla.";
RL Peptides 22:1713-1718(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hypotensive peptide. May function as a hormone in circulation
CC control (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the adrenomedullin family. {ECO:0000305}.
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DR EMBL; AJ001613; CAA04866.1; -; mRNA.
DR EMBL; AB055107; BAB62176.1; -; mRNA.
DR EMBL; BC123826; AAI23827.1; -; mRNA.
DR RefSeq; NP_776313.1; NM_173888.3.
DR RefSeq; XP_005215950.1; XM_005215893.3.
DR RefSeq; XP_005215951.1; XM_005215894.3.
DR RefSeq; XP_015330126.1; XM_015474640.1.
DR AlphaFoldDB; O62827; -.
DR SMR; O62827; -.
DR STRING; 9913.ENSBTAP00000028036; -.
DR PaxDb; O62827; -.
DR Ensembl; ENSBTAT00000028036; ENSBTAP00000028036; ENSBTAG00000021048.
DR GeneID; 280713; -.
DR KEGG; bta:280713; -.
DR CTD; 133; -.
DR VEuPathDB; HostDB:ENSBTAG00000021048; -.
DR VGNC; VGNC:25681; ADM.
DR eggNOG; ENOG502S4SF; Eukaryota.
DR GeneTree; ENSGT00940000154380; -.
DR HOGENOM; CLU_099291_1_0_1; -.
DR InParanoid; O62827; -.
DR OMA; QSFLYCC; -.
DR OrthoDB; 1555764at2759; -.
DR TreeFam; TF333447; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000021048; Expressed in uterine cervix and 105 other tissues.
DR ExpressionAtlas; O62827; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031700; F:adrenomedullin receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010460; P:positive regulation of heart rate; IBA:GO_Central.
DR GO; GO:0003073; P:regulation of systemic arterial blood pressure; IBA:GO_Central.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR001710; Pro-ADM.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00801; ADRENOMEDULN.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250|UniProtKB:P53366"
FT PEPTIDE 22..41
FT /note="Proadrenomedullin N-20 terminal peptide"
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000953"
FT PROPEP 45..92
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000954"
FT PEPTIDE 95..146
FT /note="Adrenomedullin"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT /id="PRO_0000000955"
FT PEPTIDE 105..120
FT /note="Adrenomedullin-11-26"
FT /evidence="ECO:0000269|PubMed:11754956"
FT /id="PRO_0000246182"
FT PROPEP 153..188
FT /note="PreproAM C-terminal fragment"
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000956"
FT REGION 69..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Arginine amide"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT MOD_RES 146
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT DISULFID 110..115
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT CONFLICT 9
FT /note="L -> M (in Ref. 1; CAA04866)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 188 AA; 20963 MW; 6102E69A756DCA86 CRC64;
MKLVPVALLY LGSLAFLGVD TARLDVAAEF RKKWNKWALS RGKRELRESS SYPTGLADVK
AGPVQTLIRP QDVKGASRSP QASSPDAARI RVKRYRQSLN NFQGLRSFGC RFGTCTVQKL
AHQIYHFTDK DKDGSAPRSK ISPQGYGRRR RRSLPEAGLG RTLLQPPEPK LRGAPDSRVH
QVLATLRI
