ADML_PIG
ID ADML_PIG Reviewed; 188 AA.
AC P53366;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Pro-adrenomedullin;
DE Contains:
DE RecName: Full=Adrenomedullin;
DE Short=AM;
DE Contains:
DE RecName: Full=Proadrenomedullin N-20 terminal peptide;
DE AltName: Full=ProAM N-terminal 20 peptide;
DE Short=PAMP;
DE Short=ProAM-N20;
DE Flags: Precursor;
GN Name=ADM; Synonyms=AM;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adrenal medulla;
RX PubMed=8043068; DOI=10.1016/0014-5793(94)80289-0;
RA Kitamura K., Kangawa K., Kojima M., Ichiki Y., Matsuo H., Eto T.;
RT "Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA
RT encoding its precursor.";
RL FEBS Lett. 338:306-310(1994).
RN [2]
RP PROTEIN SEQUENCE OF 22-41.
RC TISSUE=Adrenal medulla;
RX PubMed=8076689; DOI=10.1016/0014-5793(94)00810-8;
RA Kitamura K., Kangawa K., Ishiyama Y., Washimine H., Ichiki Y., Kawamoto M.,
RA Minamino N., Matsuo H., Eto T.;
RT "Identification and hypotensive activity of proadrenomedullin N-terminal 20
RT peptide (PAMP).";
RL FEBS Lett. 351:35-37(1994).
CC -!- FUNCTION: AM and PAMP are potent hypotensive and vasodilatator agents.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in adrenal glands, lung and
CC kidney.
CC -!- SIMILARITY: Belongs to the adrenomedullin family. {ECO:0000305}.
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DR EMBL; D14875; BAA03590.1; -; mRNA.
DR PIR; S41600; S41600.
DR RefSeq; NP_999272.1; NM_214107.1.
DR AlphaFoldDB; P53366; -.
DR SMR; P53366; -.
DR STRING; 9823.ENSSSCP00000014253; -.
DR PaxDb; P53366; -.
DR PRIDE; P53366; -.
DR Ensembl; ENSSSCT00000014648; ENSSSCP00000014253; ENSSSCG00000013408.
DR Ensembl; ENSSSCT00005064453; ENSSSCP00005039827; ENSSSCG00005040268.
DR Ensembl; ENSSSCT00015085686; ENSSSCP00015034825; ENSSSCG00015063932.
DR Ensembl; ENSSSCT00025029364; ENSSSCP00025012475; ENSSSCG00025021598.
DR Ensembl; ENSSSCT00030030777; ENSSSCP00030013830; ENSSSCG00030022171.
DR Ensembl; ENSSSCT00035036738; ENSSSCP00035014630; ENSSSCG00035027779.
DR Ensembl; ENSSSCT00040063807; ENSSSCP00040026947; ENSSSCG00040047373.
DR Ensembl; ENSSSCT00045026751; ENSSSCP00045018467; ENSSSCG00045015757.
DR Ensembl; ENSSSCT00050061343; ENSSSCP00050026375; ENSSSCG00050045069.
DR Ensembl; ENSSSCT00055038917; ENSSSCP00055030947; ENSSSCG00055019852.
DR Ensembl; ENSSSCT00060045441; ENSSSCP00060019461; ENSSSCG00060033515.
DR Ensembl; ENSSSCT00065110018; ENSSSCP00065049518; ENSSSCG00065079164.
DR Ensembl; ENSSSCT00070024668; ENSSSCP00070020418; ENSSSCG00070012637.
DR GeneID; 397195; -.
DR KEGG; ssc:397195; -.
DR CTD; 133; -.
DR VGNC; VGNC:85144; ADM.
DR eggNOG; ENOG502S4SF; Eukaryota.
DR GeneTree; ENSGT00940000154380; -.
DR HOGENOM; CLU_099291_1_0_1; -.
DR InParanoid; P53366; -.
DR OMA; QSFLYCC; -.
DR OrthoDB; 1555764at2759; -.
DR TreeFam; TF333447; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000013408; Expressed in granulosa cell and 39 other tissues.
DR Genevisible; P53366; SS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031700; F:adrenomedullin receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0097647; P:amylin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0043116; P:negative regulation of vascular permeability; IEA:Ensembl.
DR GO; GO:0045906; P:negative regulation of vasoconstriction; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IBA:GO_Central.
DR GO; GO:2001214; P:positive regulation of vasculogenesis; IEA:Ensembl.
DR GO; GO:0003073; P:regulation of systemic arterial blood pressure; IBA:GO_Central.
DR GO; GO:0035809; P:regulation of urine volume; IEA:Ensembl.
DR GO; GO:0060712; P:spongiotrophoblast layer development; IEA:Ensembl.
DR GO; GO:0097084; P:vascular associated smooth muscle cell development; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR001710; Pro-ADM.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00801; ADRENOMEDULN.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:8076689"
FT PEPTIDE 22..41
FT /note="Proadrenomedullin N-20 terminal peptide"
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000969"
FT PROPEP 45..92
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000970"
FT PEPTIDE 95..146
FT /note="Adrenomedullin"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT /id="PRO_0000000971"
FT PROPEP 153..188
FT /note="PreproAM C-terminal fragment"
FT /evidence="ECO:0000250|UniProtKB:P43145"
FT /id="PRO_0000000972"
FT REGION 131..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Arginine amide"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT MOD_RES 146
FT /note="Tyrosine amide"
FT /evidence="ECO:0000250|UniProtKB:P35318"
FT DISULFID 110..115
FT /evidence="ECO:0000250|UniProtKB:P35318"
SQ SEQUENCE 188 AA; 20893 MW; 71749460F5660A61 CRC64;
MKLVPVALMY LGSLAFLGAD TARLDVAAEF RKKWNKWALS RGKRELRLSS SYPTGIADLK
AGPAQTVIRP QDVKGSSRSP QASIPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL
AHQIYQFTDK DKDGVAPRSK ISPQGYGRRR RRSLPEASLG RTLRSQEPQA HGAPASPAHQ
VLATLFRI
