ADM_ARATH
ID ADM_ARATH Reviewed; 264 AA.
AC Q9SZ59;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein ADMETOS {ECO:0000303|PubMed:24012484};
GN Name=ADM {ECO:0000303|PubMed:24012484};
GN OrderedLocusNames=At4g11940 {ECO:0000312|Araport:AT4G11940};
GN ORFNames=F16J13.10 {ECO:0000312|EMBL:CAB40935.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=21257907; DOI=10.1073/pnas.1019273108;
RA Hsieh T.-F., Shin J., Uzawa R., Silva P., Cohen S., Bauer M.J.,
RA Hashimoto M., Kirkbride R.C., Harada J.J., Zilberman D., Fischer R.L.;
RT "Regulation of imprinted gene expression in Arabidopsis endosperm.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:1755-1762(2011).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=24012484; DOI=10.1016/j.devcel.2013.08.006;
RA Kradolfer D., Wolff P., Jiang H., Siretskiy A., Koehler C.;
RT "An imprinted gene underlies postzygotic reproductive isolation in
RT Arabidopsis thaliana.";
RL Dev. Cell 26:525-535(2013).
CC -!- FUNCTION: Product of a dosage-sensitive gene that contributes to the
CC maintenance of paternally and maternally imprinted gene expression in
CC the endosperm in order to balance parental contributions. Underlies
CC postzygotic reproductive isolation by promoting triploid seed arrest in
CC a genetic dosage-dependent manner, thus being a component of
CC postzygotic interploidy hybridization barriers.
CC {ECO:0000269|PubMed:24012484}.
CC -!- TISSUE SPECIFICITY: Paternally imprinted expression in the endosperm.
CC {ECO:0000269|PubMed:21257907, ECO:0000269|PubMed:24012484}.
CC -!- DISRUPTION PHENOTYPE: Suppressor of the triploid seed abortion
CC phenotype observed in osd1 and jas-3 mutants, thus leading to enlarged
CC and somewhat fertile triploid seeds production characterized by
CC abnormally normalized parental imprinted genes expression.
CC {ECO:0000269|PubMed:24012484}.
CC -!- MISCELLANEOUS: In Greek mythology, 'Admetos' was one of Jason's
CC companions Argonauts in his quest for the Golden Fleece.
CC {ECO:0000303|PubMed:24012484}.
CC -!- MISCELLANEOUS: Product of a paternally expressed imprinted gene (PEG).
CC {ECO:0000305|PubMed:21257907}.
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DR EMBL; AL049638; CAB40935.1; -; Genomic_DNA.
DR EMBL; AL161533; CAB78237.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83072.1; -; Genomic_DNA.
DR EMBL; DQ446823; ABE65520.1; -; Genomic_DNA.
DR PIR; T06601; T06601.
DR RefSeq; NP_192931.1; NM_117264.1.
DR AlphaFoldDB; Q9SZ59; -.
DR STRING; 3702.AT4G11940.1; -.
DR PaxDb; Q9SZ59; -.
DR PRIDE; Q9SZ59; -.
DR EnsemblPlants; AT4G11940.1; AT4G11940.1; AT4G11940.
DR GeneID; 826801; -.
DR Gramene; AT4G11940.1; AT4G11940.1; AT4G11940.
DR KEGG; ath:AT4G11940; -.
DR Araport; AT4G11940; -.
DR TAIR; locus:2118016; AT4G11940.
DR HOGENOM; CLU_1024319_0_0_1; -.
DR OMA; NLEPQGN; -.
DR OrthoDB; 1595465at2759; -.
DR PhylomeDB; Q9SZ59; -.
DR PRO; PR:Q9SZ59; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SZ59; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0009960; P:endosperm development; IGI:TAIR.
DR GO; GO:0080155; P:regulation of double fertilization forming a zygote and endosperm; IMP:UniProtKB.
DR GO; GO:2000653; P:regulation of genetic imprinting; IMP:UniProtKB.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..264
FT /note="Protein ADMETOS"
FT /id="PRO_0000441607"
SQ SEQUENCE 264 AA; 29902 MW; E81AA90472B0C616 CRC64;
MFSGEGASQI RIAPEDKPIQ WCYQILKSRD FKSARYITQM NLKLSKTRHD EYEKGLAICD
ILIAAENRLP NGLLDCYGMI RMTRPGLVLY QNIEKELNLL GWGNISNPFP FRQEASEKFF
FAWSLLSNPT IKEMYDYATS DEVNLEPQGN VNEYMDVDSS SQSGYGLGSV LCSDLPGSEY
LKEFADVYPL PLAEKGQAPH NRFGWYDHNV GPETNNNVVV TYEDAKEEEC DMSSSSELRI
INGRRVKITI EEAAETSDTP SCSR
